产品名称

英文名称：Omecamtiv mecarbil (CK-1827452)

同义词

Omecamtiv mecarbil、873697-71-3、Omecamtiv mecarbil (CK-1827452)、CK-1827452、methyl 4-(2-fluoro-3-(3-(6-Methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate、CK1827452、CK 1827452、AMG-423、Methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]

产品性质

CAS编号：873697-71-3

分子式：C20H24FN5O3

分子量：401.43

PubChem编号：11689883

英文别名：Omecamtiv mecarbil|873697-71-3|Omecamtiv mecarbil (CK-1827452)|CK-1827452|methyl 4-(2-fluoro-3-(3-(6-Methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate|CK1827452|CK 1827452|AMG-423|Methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]

规格或纯度：≥98%

英文名称：Omecamtiv mecarbil (CK-1827452)

生化机理：Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an EC50 of 0.6 μM.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

ALogP：1.4

IUPAC Name：methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate

INCHI：InChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27)

InChi Key：RFUBTTPMWSKEIW-UHFFFAOYSA-N

Canonical SMILES：CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC

Isomeric SMILES：CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC

PubChem CID：11689883

ChEMBL Ligand：CHEMBL1800955

CAS Registry No.：873697-71-3

RCSB PDB Ligand：2OW

溶解性：DMSO 80 mg/mL Water <1 mg/mL Ethanol 6 mg/mL

象形图：

信号词：Danger

危险声明：H372 Causes damage to organs through prolonged or repeated exposureH370 Causes damage to organs

预防措施声明：P321,P405,P501,P264,P260,P270,P308+P316,P319

产品包装