产品名称

英文名称：ZM 323881 HCl

同义词

5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride;ZM-323881 hydrochloride、Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-, hydrochloride (11)

产品性质

CAS编号：193000-39-4

分子式：C22H18FN3O2·HCl

分子量：411.86

PubChem编号：22624897

别名：Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-, hydrochloride (11)

英文别名：5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride;ZM-323881 hydrochloride

规格或纯度：≥99%

英文名称：ZM 323881 HCl

生化机理：ZM323881 is a selective inhibitor of VEGFR-2 with an IC50 value of 2 nM. ZM323881 is selective for VEGFR-2 over VEGFR-1 and other receptor tyrosine kinases including PDGFRβ, FGFR1, EGFR and erbB2. ZM323881 inhibited VEGF-A-induced endothelial cell proliferation with an IC50 value of 8 nM. ZM323881 is also known as (5‐{[7‐(benzyloxy) quinazolin‐4‐yl]amino}‐4‐fluoro‐2‐methylphenol). It is capable of blocking the efflux function and altering breast cancer resistant protein (BCRP)-related multidrug resistance (MDR).

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：4-fluoro-2-methyl-5-[(7-phenylmethoxyquinazolin-4-yl)amino]phenol;hydrochloride

INCHI：InChI=1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H

InChi Key：AVRHWGLIYGJSOD-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=C(C=C1O)NC2=NC=NC3=C2C=CC(=C3)OCC4=CC=CC=C4)F.Cl

Isomeric SMILES：CC1=CC(=C(C=C1O)NC2=NC=NC3=C2C=CC(=C3)OCC4=CC=CC=C4)F.Cl

PubChem CID：22624897

溶解性：溶于DMSO, 最高浓度 (mg/mL) 20.59, 最高浓度(mM) 50

敏感性：对湿度敏感

产品包装