产品名称

英文名称：Mizoribine

同义词

4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate、HE-69、HMS3262E12、Mizoribine (Bredinin)、N-Methyl-5-phenyl-5-ethylbarbituric acid、SCHEMBL7118、BRN 4151713、HY-17470、J-521362、1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydrox、咪唑立宾

产品性质

CAS编号：50924-49-7

分子式：C9H13N3O6

分子量：259.22

MDL号：MFCD00057221

PubChem编号：104762

别名：咪唑立宾

英文别名：4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate|HE-69|HMS3262E12|Mizoribine (Bredinin)|N-Methyl-5-phenyl-5-ethylbarbituric acid|SCHEMBL7118|BRN 4151713|HY-17470|J-521362|1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydrox

规格或纯度：≥98%

英文名称：Mizoribine

生化机理：Mizoribine is an imidazole nucleoside immunosuppressant agent that was first isolated from the mold Eupenicillium brefeldimium with antibiotic and cytotoxic effects. In a mouse model for IgA nephropathy, Mizoribine was documented to influence the proliferation of B cells and decrease the glomerular IgA load while increasing glomerular expansion. In addition in human B cells the compound has been observed to Inhibit the expression of cyclin A. The immunosuppressive effects of Mizoribine Hydrobromide also effects T cells throμgh suppression of G to S phase transition. In the case of puromycin aminonucleoside nephropathy Mizoribine demonstrated the ability to prevent podocyte injury. The compound has also been documented to induce the differentiation of promyelocytes on a mechansim relying on impaired guanine nucleotide synthesis.Imidazole nucleoside. Immunosuppressive agent. HCV RNA replication inhibitor (IC 50 = 100 μM). Inhibits T and B cell proliferation. Anti-bacterial, antiviral, antibiotic, anti-inflammatory and immunosuppressive agent. Active in vivo and in vitro .

应用：An imidazole nucleoside immunosuppressant agent.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Mizoribine 是一种咪唑核苷，是一种免疫抑制剂，IC50约为100μMAn imidazole nucleoside immunosuppressant agent.Mizoribine is an imidazole nucleoside, selectively inhibits inosine monophosphate synthetase and guanosine monophosphate synthetaseAn imidazole nucleoside immunosuppressant agent.

IUPAC Name：1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide

INCHI：InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1

InChi Key：HZQDCMWJEBCWBR-UUOKFMHZSA-N

Canonical SMILES：C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N

Isomeric SMILES：C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)N

WGK Germany：3

RTECS：NI3980000

PubChem CID：104762

Reaxy-Rn：8155135

溶解性：Soluble in water (52 mg/ml), DMSO (52 mg/ml), ethanol (<1 mg/ml), and methanol

敏感性：对热敏感

比旋光度：-26° (C=2,H2O)

熔点：198 °C(dec.)

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317,P319

Merck Index：6222

个人防护装备：Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装