产品名称

英文名称：ZM 336372

同义词

208260-29-1、ZM 336372、ZM336372、ZM-336372、3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide、N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide、CHEMBL186526、n-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamid

产品性质

CAS编号：208260-29-1

分子式：C23H23N3O3

分子量：389.45

MDL号：MFCD02683971

PubChem编号：5730

英文别名：208260-29-1|ZM 336372|ZM336372|ZM-336372|3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide|N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide|CHEMBL186526|n-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamid

规格或纯度：≥98%

英文名称：ZM 336372

生化机理：ZM 336372 is a reversible, selective inhibitor of the protein kinase Raf-1 (IC50 = 70nM). Althoμgh ZM 336372 weakly inhibits Raf-B, it is 10 fold more potent against Raf-1 and so is considered more selective towards this kinase. ZM 336372 inhibits Raf-1 by competing with ATP to bind to the protein. Alternate studies sμggest that ZM 336372 can induce apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β (GSK-3β) throμgh phosphorylation of GSK-3&beta at Ser 9. In addition, ZM 336372 can suppress the proliferation of hepatocellular carcinoma cells by inhibiting hormone secretion and up-regulating cell cycle inhibitors. Furthermore, ZM 336372 can also act as an agonist towards Raf-1, activating the MAPK pathway, which can be suppressed after activation by Raf-1 itself, using a novel feedback loop in which activation is always followed by inactivation. ZM 336372 is an inhibitor of p38 α and p38 β.Potent, cell-permeable and selective c-Raf inhibitor (IC 50 = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：ZM 336372是一种有效的，选择性的c-Raf抑制剂，IC50为70 nM，比作用于B-RAF选择性高10倍，对PKA/B/C， AMPK， p70S6等没有抑制作用。A potent and selective Raf-1 inhibitor.ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc.A potent and selective Raf-1 inhibitor.

IUPAC Name：3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide

INCHI：InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)

InChi Key：PYEFPDQFAZNXLI-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O

Isomeric SMILES：CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O

WGK Germany：3

关联CAS：208260-29-1

PubChem CID：5730

MeSH Entry Terms：N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide;ZM 336372;ZM-336372;ZM336372

溶解性：Soluble in DMSO (200 mg/ml), DMF (~20 mg/ml), water (0.5 mg/ml at 25 °C), and ethanol (2 mg/ml at 25 °C).

敏感性：对光敏感

产品包装