产品名称

英文名称：4-Pyrazoleboronic acid pinacol ester

同义词

269410-08-4、4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole、Pyrazole-4-boronic acid pinacol ester、4-Pyrazoleboronic acid pinacol ester、1h-pyrazole-4-boronic acid pinacol ester、pyrazole-4-boronic acid, pinacol ester、4-(tetramethyl-1,3,2-dioxabo、1H-吡唑-4-硼酸频哪醇酯、4-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)吡唑、吡唑-4-硼酸凤梨醇酯、2-二氧硼烷-2-基)-1H-吡唑、4,4,5,5-四甲基-2-(1H-吡唑-4-基)-1,3,2-二氧杂戊硼烷

产品性质

CAS编号：269410-08-4

分子式：(CH3)4C2O2BC3N2H3

分子量：194.04

MDL号：MFCD03453063

PubChem编号：2774010

别名：1H-吡唑-4-硼酸频哪醇酯|4-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)吡唑|吡唑-4-硼酸凤梨醇酯|2-二氧硼烷-2-基)-1H-吡唑|4,4,5,5-四甲基-2-(1H-吡唑-4-基)-1,3,2-二氧杂戊硼烷

英文别名：269410-08-4|4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|Pyrazole-4-boronic acid pinacol ester|4-Pyrazoleboronic acid pinacol ester|1h-pyrazole-4-boronic acid pinacol ester|pyrazole-4-boronic acid, pinacol ester|4-(tetramethyl-1,3,2-dioxabo

规格或纯度：98%

英文名称：4-Pyrazoleboronic acid pinacol ester

运输条件：常规运输

产品介绍：应用Suzuki-Miyaura 交叉耦合；钌催化不对称氢化；用于制备含优势骨架吡唑的许多非常重要的治疗酶和激酶的抑制剂的试剂，包括VEGF，极光，Rho（岩石），Janus 激酶 2 (JAK)，c-MET，ALK，S-亚硝基谷胱甘肽还原酶，CDC7，乙酰辅酶A羧化酶促存活 Bcl-2 蛋白，病毒 RNA 依赖性 RNA 聚合酶，长链脂肪酸延长酶 6，PI3，AKT，Chk1，蛋白激酶 B；1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

PubChem SID：488193563

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488193563

IUPAC Name：4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

INCHI：InChI=1S/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)

InChi Key：TVOJIBGZFYMWDT-UHFFFAOYSA-N

Canonical SMILES：B1(OC(C(O1)(C)C)(C)C)C2=CNN=C2

Isomeric SMILES：B1(OC(C(O1)(C)C)(C)C)C2=CNN=C2

WGK Germany：3

PubChem CID：2774010

Reaxy-Rn：11072822

溶解性：不溶于水，可溶于甲醇

熔点：145-149°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装