产品名称

英文名称：Minocycline hydrochloride

同义词

MINOCYCLINE HYDROCHLORIDE、13614-98-7、Minocycline HCl、Arestin、Solodyn、Minomycin、Minocin、Dynacin、Periocline、Ximino、Minocycline (hydrochloride)、Vectrin、Minomax、(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-、盐酸米诺环素,盐酸二甲胺四环素

产品性质

CAS编号：13614-98-7

分子式：C23H27N3O7.HCl

分子量：493.94

EC号：237-099-7

MDL号：MFCD00083669

PubChem编号：54685925

别名：盐酸米诺环素,盐酸二甲胺四环素

英文别名：MINOCYCLINE HYDROCHLORIDE|13614-98-7|Minocycline HCl|Arestin|Solodyn|Minomycin|Minocin|Dynacin|Periocline|Ximino|Minocycline (hydrochloride)|Vectrin|Minomax|(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-

规格或纯度：≥98%

英文名称：Minocycline hydrochloride

生化机理：Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Minocycline acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Minocycline also inhibit the enzymatic activity of poly(ADP-ribose) polymerase-1 (PARP-1) and angiogenesis. In addition, Minocycline is sμggested to down-regulate CD40L on T cells and inhibit the replication of SIV and HIV. Orally active and brain penetrant.Antibiotic. Demonstrates anti-inflammatory, antiapoptotic, antioxidant and neuroprotective effects. Blood-brain barrier permeable. Matrix metalloproteinase (MMP) inhibitor (IC 50 = 290 μM at stromelysin (MMP-3).

应用：抑制内皮细胞扩增和血管发生。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：溶于水，遇光不稳定，味苦。抑制内皮细胞扩增和血管发生。Minocycline hydrochloride has been used · to prepare nanoliposomes to check its effect on macrophages · for the inhibition of neuroinflammation and neuropathic pain · to treat glioma in murine GL261 glioma cells

IUPAC Name：(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride

INCHI：InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1

InChi Key：WTJXVDPDEQKTCV-VQAITOIOSA-N

Canonical SMILES：CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl

Isomeric SMILES：CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl

WGK Germany：3

RTECS：QI7630500

PubChem CID：54685925

Reaxy-Rn：4836328

溶解性：Freely soluble in water

密度：1.017

敏感性：对热敏感

比旋光度：-170 to -180 deg(C=0.5、0.1mol/L HCl)

闪点(℉)：230°F

闪点(℃)：>110℃

沸点：813℃

熔点：205-210℃

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P263,P203,P264+P265,P318,P337+P317,P332+P317,P319

Merck Index：6202

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

产品包装