产品名称

英文名称：Lonidamine

同义词

lonidamine、50264-69-2、1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid、Diclondazolic acid、Doridamina、DICA、Lonidamina、Lonidaminum、1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid、Lonidamin、AF 1890、C15H10Cl2N2O2、1-(2,4-Dichlorbenzyl)-indazol、诺尼达明,1-(2,4-二氯苄基)-1H-吲唑-3-羧酸, 二癸酸,洛尼达酸

产品性质

CAS编号：50264-69-2

分子式：C15H10Cl2N2O2

分子量：321.16

EC号：256-510-0

MDL号：MFCD00866285

PubChem编号：39562

别名：诺尼达明,1-(2,4-二氯苄基)-1H-吲唑-3-羧酸, 二癸酸,洛尼达酸

英文别名：lonidamine|50264-69-2|1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid|Diclondazolic acid|Doridamina|DICA|Lonidamina|Lonidaminum|1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid|Lonidamin|AF 1890|C15H10Cl2N2O2|1-(2,4-Dichlorbenzyl)-indazol

规格或纯度：≥99%

英文名称：Lonidamine

生化机理：通过干扰己糖激酶和干扰非偶联刺激的线粒体电子传递来抑制肿瘤细胞的能量代谢；损伤细胞和线粒体膜

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：5mg卖完停产，不再备货；如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Product DescribtionLonidamine is an indazole compound that has been reported to inhibit angiogenic-related endothelial cell functions. This compound has been found to trigger apoptosis in endothelial cells and cause a decrease in proliferation, migration, invasion, and morphogenesis. The apoptotic effects of Lonidamine have been demonstrated to be due to Bax, Bid, caspase-3, and caspase-9 activation, as well as cytochrome c release. Futher studies show that Lonidamine prevents cellular energy metabolism via HXK (hexokinase) inhibition. This compound also blocks CFTR Cl- channels in vitro.It elicits cell apoptosis and blocks CFTR Cl- channel.

IUPAC Name：1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid

INCHI：InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)

InChi Key：WDRYRZXSPDWGEB-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O

Isomeric SMILES：C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O

WGK Germany：3

关联CAS：50264-69-2

PubChem CID：39562

NSC Number：741419

MeSH Entry Terms：1-(2,4-dichlorobenzyl)indazole-3-carboxylic acid;AF 1890;diclondazolic acid;lonidamine

溶解性：Soluble in ethanol (5 mM), DMSO (100 mM), CHCl3/MeOH 1/1 (9.80-10.20 mg/ml), water (<1 mg/ml at 25° C), DMSO (64 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).

敏感性：对空气敏感

熔点：210 °C

象形图：

信号词：Danger

危险声明：H351 Suspected of causing cancerH302 Harmful if swallowedH360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P270,P330,P203,P301+P317,P318

产品包装