产品名称

英文名称：Perphenazine

同义词

perphenazine、58-39-9、Trilafon、Perphenazin、Etaperazine、Perfenazine、Ethaperazine、Etaperazin、Fentazin、Chlorpiprazine、Decentan、Perphenan、Thilatazin、Chlorperphenazine、Perfenazina、Tranquisan、Triphenot、Emesinal、Trifaron、Trilifan、F-mon、Perphenazinum、2-(4-(3-(2-Ch、奋乃静、2-氯-10-[3-[4-(2-羟基乙基)哌嗪-1-基]丙基]吩噻嗪、4-[3-(2-氯吩噻嗪-10-基)丙基]-1-哌嗪乙醇、1-(2-羟乙基)-4-[3-(2-氯-10-吩噻嗪基)丙基]哌嗪

产品性质

CAS编号：58-39-9

分子式：C21H26ClN3OS

分子量：403.97

MDL号：MFCD00056798

PubChem编号：4748

别名：奋乃静|2-氯-10-[3-[4-(2-羟基乙基)哌嗪-1-基]丙基]吩噻嗪|4-[3-(2-氯吩噻嗪-10-基)丙基]-1-哌嗪乙醇|1-(2-羟乙基)-4-[3-(2-氯-10-吩噻嗪基)丙基]哌嗪

英文别名：perphenazine|58-39-9|Trilafon|Perphenazin|Etaperazine|Perfenazine|Ethaperazine|Etaperazin|Fentazin|Chlorpiprazine|Decentan|Perphenan|Thilatazin|Chlorperphenazine|Perfenazina|Tranquisan|Triphenot|Emesinal|Trifaron|Trilifan|F-mon|Perphenazinum|2-(4-(3-(2-Ch

规格或纯度：>97.0%

英文名称：Perphenazine

生化机理：D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

应用：它是一个经典的抗精神病药物，能够抑制 5-HT2A 受体，α1A 肾上腺素能受体，多巴胺D2/D3、D2L 受体, 以及 组胺H1 受体，对应的 Ki 值分别为5.6，10，0.765/0.13，3.4 和8 nM。

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Perphenazine is an antipsychotic drμg used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drμg group in improving response to oxidative injury.它是一个经典的抗精神病药物，能够抑制 5-HT2A 受体，α1A 肾上腺素能受体，多巴胺D2/D3、D2L 受体, 以及 组胺H1 受体，对应的 Ki 值分别为5.6，10，0.765/0.13，3.4 和8 nM。Perphenazine is an antipsychotic drug used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drug group in improving response to oxidative injury.

ALogP：4.2

IUPAC Name：2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol

INCHI：InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

InChi Key：RGCVKNLCSQQDEP-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

Isomeric SMILES：C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

WGK Germany：3

RTECS：TL7175000

PubChem CID：4748

Reaxy-Rn：54730

DrugBank Ligand：DB00850

CAS Registry No.：58-39-9

ChEBI：CHEBI8028

Wikipedia：Perphenazine

ChEMBL Ligand：CHEMBL567

BindingDB Ligand：50130273

PEP：perphenazine

DrugCentral Ligand：2113

GPCRdb Ligand：perphenazine

溶解性：DMSO ≥ 4.1 mg/mL

敏感性：对热及光敏感

熔点：97 °C

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH318 Causes serious eye damageH317 May cause an allergic skin reactionH330 Fatal if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P330,P320,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P316

Merck Index：7183

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