产品名称

英文名称：Carboplatin

同义词

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) 、 1,1-Cyclobutanedicarboxylatodiammineplatinum(II)、卡波铂 、 碳铂 、 顺-二氨-1,1-环丁烷基二羟酸铂 、 顺-二氨-1,1-环丁烷基二羧酸铂 、 顺式-1,1-环丁烷二羧酸二氨铂 、 顺 - 二氨基(1,1-环丁烷二羧酸)铂 、 顺-二胺(1,1-环丁烷二羧酸)铂(II)

产品性质

CAS编号：41575-94-4

分子式：C6H12N2O4Pt

分子量：371.25

EC号：255-446-0

MDL号：MFCD00070464

PubChem编号：426756

别名：卡波铂 | 碳铂 | 顺-二氨-1,1-环丁烷基二羟酸铂 | 顺-二氨-1,1-环丁烷基二羧酸铂 | 顺式-1,1-环丁烷二羧酸二氨铂 | 顺 - 二氨基(1,1-环丁烷二羧酸)铂 | 顺-二胺(1,1-环丁烷二羧酸)铂(II)

英文别名：cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) | 1,1-Cyclobutanedicarboxylatodiammineplatinum(II)

规格或纯度：98%

英文名称：Carboplatin

生化机理：卡铂是一种铂类抗肿瘤药物，通过与邻近的鸟嘌呤残基形成链内交联来破坏DNA。肿瘤通过DNA错配修复(MMR)活性的丧失以及由此导致的程序性细胞死亡诱导的减少而获得对这些药物的抗性。抗肿瘤剂。形成阻止DNA复制和转录的铂-DNA加合物。显示出比类似物顺铂低的肾毒性。在体内有活性。

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Product DescriptionCarboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action.An antitumor agent that binds to DNA leading to apoptosisProduct ApplicationCarboplatin has been used in chemotherapy-induced thrombocytopenia mouse model and treatment to induce cell death in a large subset of colorectal cancer cells in the evaluation of cell proliferation and chemosensitivityas a positive control for suppressed cell growthProduct classhAPIs, Metal based hAPIsChemical propertiesChemical formulaC6H12N2O4PtEmpirical formula[Pt(NH3)2(cbdc)]Molecular weight371.25MetalPtTheoretical metal content53Physical statepowderColorwhite

IUPAC Name：azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)

INCHI：InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2

InChi Key：VSRXQHXAPYXROS-UHFFFAOYSA-N

Canonical SMILES：C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]

Isomeric SMILES：C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]

WGK Germany：3

RTECS：TP2300000

关联CAS：41575-94-4

PubChem CID：426756

NSC Number：201345

MeSH Entry Terms：Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo

Reaxy-Rn：13598388

ChEMBL Ligand：CHEMBL1351

CAS Registry No.：41575-94-4

Wikipedia：Carboplatin

溶解性：Soluble in water.DMSO can inactivate Carboplatin's activity.

敏感性：对光敏感

熔点：>275℃

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH302 Harmful if swallowedH317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH312 Harmful in contact with skinH332 Harmful if inhaledH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH340 May cause genetic defectsH302+H312+H332 Harmful if swallowed, in contact with skin or if inhaledH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P284,P281,P271,P270,P304+P340,P272,P333+P313,P362+P364,P330,P263,P203,P264+P265,P301+P317,P318,P317,P337+P317,P332+P317,P319,P342+P316

Merck Index：1822

个人防护装备：Eyeshields， Faceshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges

产品包装