产品名称

英文名称：Dimethyl fumarate

同义词

Dimethylfumarate 、 BG-12 、 (E)-Dimethyl fumarate 、 Boletic acid dimethyl ester 、 Methyl fumarate 、 Dimethyl (E)-but-2-enedioate 、 Fumaric acid dimethyl ester 、 Panaclar 、 Fumaric acid, dimethyl ester 、 Dimethyl fumarate 、 Tecfidera 、 Fumaderm、反丁烯二酸二甲酯,DMF 、 (E)-2-丁烯二酸二甲酯 、 延胡索酸二甲酯 、 霉克星1号

产品性质

CAS编号：624-49-7

分子式：C6H8O4

分子量：144.13

Beilstein号：774590

EC号：210-849-0

MDL号：MFCD00064438

PubChem编号：637568

别名：反丁烯二酸二甲酯,DMF | (E)-2-丁烯二酸二甲酯 | 延胡索酸二甲酯 | 霉克星1号

英文别名：Dimethylfumarate | BG-12 | (E)-Dimethyl fumarate | Boletic acid dimethyl ester | Methyl fumarate | Dimethyl (E)-but-2-enedioate | Fumaric acid dimethyl ester | Panaclar | Fumaric acid, dimethyl ester | Dimethyl fumarate | Tecfidera | Fumaderm

规格或纯度：99%

英文名称：Dimethyl fumarate

生化机理：Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator. Dimethyl fumarate induces upregulation of antioxidant gene expression. Dimethyl fumarate displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Dimethyl fumarate exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis.

运输条件：常规运输

产品介绍：具有酯香味。易升华，微溶于水，溶于乙醇。对光和热稳定,在紫外线和阳光照射下基本上72小时无变化,110℃加热2小时不分解。作用机理能顺利穿透微生物的细胞膜，抑制微生物细胞的分裂，并通过对三羧酸循环（TCAC）磷酸己糖途径（HMP）和酵解途径（EMP）的酶活性的抑制来抑制微生物的呼吸作用，从而达到抑菌作用，使微生物的生长繁殖被有效控制。applicationDimethyl fumarate can be usedIn the preparation of an adduct [dimethyl-(+)-(11R,12R)-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboxylate].As a ligand in the synthesis of Ni(II)-based catalytic system applicable in the Negishi alkylations of N-sulfonyl aziridines with organozinc reagents.As a ligand to synthesize zerovalent ruthenium metal complex namely Ru(η6-1,3,5-cyclooctatriene)(η2-dimethyl fumarate)2.Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation.

IUPAC Name：dimethyl (E)-but-2-enedioate

INCHI：InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+

InChi Key：LDCRTTXIJACKKU-ONEGZZNKSA-N

Canonical SMILES：COC(=O)C=CC(=O)OC

Isomeric SMILES：COC(=O)/C=C/C(=O)OC

WGK Germany：1

RTECS：EM6125000

PubChem CID：637568

Reaxy-Rn：774590

ChEMBL Ligand：CHEMBL2107333

CAS Registry No.：624-49-7

DrugBank Ligand：DB08908

Wikipedia：Dimethyl_fumarate

PEP：dimethyl fumarate

RCSB PDB Ligand：EOU

DrugCentral Ligand：4757

溶解性：Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).

密度：1.37

沸点：193°C

熔点：103—104°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH411 Toxic to aquatic life with long lasting effectsH317 May cause an allergic skin reactionH312 Harmful in contact with skin

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P272,P333+P313,P362+P364,P391,P264+P265,P317,P337+P317,P332+P317,P319

Merck Index：4287

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

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