产品名称

英文名称：astemizole

同义词

astemizole、68844-77-9、Hismanal、Histaminos、Paralergin、Laridal、Retolen、Astemison、Histamen、Kelp、Astemizol、Astemizolum、1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine、1-(p-Fluorobenzyl)-2-((1-(p-methoxypheneth、阿司咪唑、1-(4-氟苄基)-2-(1-[4-甲氧基苯乙基] 哌啶-4-基)氨基苯并咪唑

产品性质

CAS编号：68844-77-9

分子式：C28H31FN4O

分子量：458.57

EC号：272-441-9

MDL号：MFCD00153919

PubChem编号：2247

别名：阿司咪唑|1-(4-氟苄基)-2-(1-[4-甲氧基苯乙基] 哌啶-4-基)氨基苯并咪唑

英文别名：astemizole|68844-77-9|Hismanal|Histaminos|Paralergin|Laridal|Retolen|Astemison|Histamen|Kelp|Astemizol|Astemizolum|1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine|1-(p-Fluorobenzyl)-2-((1-(p-methoxypheneth

规格或纯度：≥98%

英文名称：astemizole

生化机理：Astermizole is a potent hERG potassium channel blocker (IC50 of 0.9 nM) and may used as a pharmacological chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels. It has also been studied for treatment of malaria, hERG and hEAG channel function in cancer and as a second generation antihistamine H-1 antagonist.Potent, selective histamine H1 receptor antagonist (IC 50 = 4 nM) and potent hERG K + channel blocker (IC 50 =0.9 nM). Orally active. Antiallergic agent. Active in vivo and in vitro .

储存温度：2-8°C储存,避光

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

ALogP：6

IUPAC Name：1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine

INCHI：InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)

InChi Key：GXDALQBWZGODGZ-UHFFFAOYSA-N

Canonical SMILES：COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F

Isomeric SMILES：COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F

WGK Germany：3

RTECS：DD8968000

PubChem CID：2247

DrugBank Ligand：DB00637

CAS Registry No.：68844-77-9

ChEBI：CHEBI2896

ChEMBL Ligand：CHEMBL296419

BindingDB Ligand：24226

Wikipedia：Astemizole

RCSB PDB Ligand：XB7

DrugCentral Ligand：249

GPCRdb Ligand：astemizole

溶解性：It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).

敏感性：对光线敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装