产品名称

英文名称：N-Succinimidyl 4-(N-Maleimidomethyl) cyclohexanecarboxylate

同义词

SMCC、64987-85-5、71875-81-5、2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate、TRANS-4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID-NHS、N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate、N-Succinimidyl 4、N-琥珀酰亚胺基4-(马来酰亚胺基甲基)环己烷羧酸酯、4-[(2,5-二氧代-2,5-二氢-1H-吡咯-1-基)甲基]环己烷-1-甲酸2,5-二氧代吡咯烷-1-基酯

产品性质

CAS编号：64987-85-5

分子式：C16H18N2O6

分子量：334.33

MDL号：MFCD00009634

PubChem编号：125175

别名：N-琥珀酰亚胺基4-(马来酰亚胺基甲基)环己烷羧酸酯|4-[(2,5-二氧代-2,5-二氢-1H-吡咯-1-基)甲基]环己烷-1-甲酸2,5-二氧代吡咯烷-1-基酯

英文别名：SMCC|64987-85-5|71875-81-5|2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate|TRANS-4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID-NHS|N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate|N-Succinimidyl 4

规格或纯度：>98.0%(HPLC)

英文名称：N-Succinimidyl 4-(N-Maleimidomethyl) cyclohexanecarboxylate

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：4-（N-马来酰亚胺基甲基）环己烷羧酸 N-羟基琥珀酰亚胺酯（SMCC）是一种异双功能交联剂，其包含一个具有胺和巯基反应性的延长间隔基。[1]它通常首先通过酰胺键（pH7.5（6.5-8.5）缓冲）与含有伯胺的分子进行偶联。第二次偶联通过硫醚键（pH6.8（6.5-7.0）缓冲）与含有游离巯基的分子进行特异性偶联。SMCC包含九个原子连接子。与芳族间隔基相比，延伸的脂族间隔基可在偶联之前稳定马来酰亚胺。4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.

IUPAC Name：(2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate

INCHI：InChI=1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2

InChi Key：JJAHTWIKCUJRDK-UHFFFAOYSA-N

Canonical SMILES：C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)ON3C(=O)CCC3=O

Isomeric SMILES：C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)ON3C(=O)CCC3=O

PubChem CID：125175

Reaxy-Rn：1555271

敏感性：对热敏感 ;对光线敏感 ;对湿度敏感

熔点：177 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritation

预防措施声明：P305+P351+P338

产品包装