产品名称

英文名称：Trifluridine

同义词

Trifluridine、TRIFLUOROTHYMIDINE、70-00-8、Viroptic、5-Trifluorothymidine、Trifluoromethyldeoxyuridine、F3DThd、Trifluridina、Trifluridinum、Virophta、5-(Trifluoromethyl)deoxyuridine、F3TDR、TFDU、5-Trifluoromethyl-2-deoxyuridine、Trifluorothymine deoxyriboside、5-Trifl、α,α,α-三氟胸苷、三氟尿苷、2‘-脱氧-5-三氟甲基尿苷

产品性质

CAS编号：70-00-8

分子式：C10H11F3N2O5

分子量：296.2

EC号：200-722-8

MDL号：MFCD00006534

PubChem编号：6256

别名：α,α,α-三氟胸苷|三氟尿苷|2‘-脱氧-5-三氟甲基尿苷

英文别名：Trifluridine|TRIFLUOROTHYMIDINE|70-00-8|Viroptic|5-Trifluorothymidine|Trifluoromethyldeoxyuridine|F3DThd|Trifluridina|Trifluridinum|Virophta|5-(Trifluoromethyl)deoxyuridine|F3TDR|TFDU|5-Trifluoromethyl-2-deoxyuridine|Trifluorothymine deoxyriboside|5-Trifl

规格或纯度：≥98%

英文名称：Trifluridine

生化机理：DescriptionIC50 Value 1 uM ( Hela cell) [1]Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drμg, used primarily on the eye. Trifluorothymidine (TFT) is well known to be converted to TFT-monophosphate by thymidine kinase and to inhibit thymidylate synthasein vitro When HeLa cells were treated with TFT at a concentration of 1 ?M (IC50 value), the concentration of TFT in the DNA was calculated as 62.2±0.9 pmol/1x106 cells for 4 h [1]. Unlike FdUrd and 5FU, TFT resulted in an earlier phosphorylation of ATR and chk1 proteins after only 24 h of exposure, while phosphorylated ATM, BRCA2 and chk2 proteins were detected after more than 48 h of exposure to TFT [2]. SN38 and TFT induced most DNA damage in H630 and Colo320 cells, which was increased in combination. TFT pre-incubation further enhanced SN38-induced DNA strand breaks in H630 and Colo320 (>20%), which was most pronounced in H630 cells (p<0.01) [3].Selective antiherpesvirus agent. Thymidine analog. Inhibits thymidylate synthase. Induces DNA damage and shows cytotoxic effects (IC 50 = 1 μM). Orally active.

应用：三氟胸苷 (TFT) 是一种用于研究胸苷激酶特异性和动力学的底物。磷酸化后的 TFT 可掺入 DNA，诱导 DNA 损伤，因此 TFT 可用于研究 DNA 修复机制。TFT 也可用于研究胸苷酸合成酶抑制机制。

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Trifluridine 是一种抗疱疹病毒药，主要用于眼部。 三氟胸苷 (TFT) 是一种用于研究胸苷激酶特异性和动力学的底物。磷酸化后的 TFT 可掺入 DNA，诱导 DNA 损伤，因此 TFT 可用于研究 DNA 修复机制。TFT 也可用于研究胸苷酸合成酶抑制机制。Trifluridine is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

ALogP：-0.5

IUPAC Name：1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione

INCHI：InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1

InChi Key：VSQQQLOSPVPRAZ-RRKCRQDMSA-N

Canonical SMILES：C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O

Isomeric SMILES：C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O

RTECS：XP2087500

关联CAS：70-00-8

PubChem CID：6256

MeSH Entry Terms：2'-deoxy-5-(trifluoromethyl)uridine;5 Trifluoromethyl 2' deoxyuridine;5-Trifluoromethyl-2'-deoxyuridine;TFT Ophtiole;Triflumann;Trifluoridine;Trifluorothymidine;Trifluridine;Viromidin;Virophta;Viroptic

Reaxy-Rn：568095

溶解性：DMSO 59 mg/mL Water 59 mg/mL Ethanol 59 mg/mL

敏感性：对湿度敏感

比旋光度：+47.0 ～ +53.0°(C=1,H2O)

熔点：189°C

象形图：

信号词：Warning

危险声明：H351 Suspected of causing cancerH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaled

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P362+P364,P330,P203,P301+P317,P318,P317

Merck Index：9687

产品包装