产品名称

英文名称：Calmodulin from bovine testes

同义词

磷酸二酯酶 3'5'-环核苷酸活化剂

产品性质

CAS编号：77107-46-1

别名：磷酸二酯酶 3'5'-环核苷酸活化剂

规格或纯度：≥98% (SDS-PAGE)

英文名称：Calmodulin from bovine testes

生化机理：环核苷酸依赖性磷酸二酯酶活化所需的 Ca2+ 结合蛋白。它也是一氧化氮合成酶、钙调磷酸酶以及多种激酶的辅因子/活化剂，这些激酶包括 ATP 酶、肌球蛋白轻链激酶和 CAM 激酶 I、II、III。它通过环二磷酸腺苷核糖介导利阿诺定受体活化并且与细胞内 Ca2+ 的内稳态有关。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：牛钙调蛋白具有哑铃式结构。两个钙结合EF手环、反平行β片和三个α螺旋线组成一个叶。它有一个与叶相连的中心螺旋线。钙调蛋白能以协同交互方式结合四个钙分子。应用使用牛钙调蛋白对重组维甲酸诱导基因I蛋白进行体外磷酸化分析。此外，它还用于内源性蛋白酶Glu-C蛋白水解和脱酰胺研究。Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory. Many proteins use Calmodulin as a calcium sensor and signal transducer, as the proteins themselves are not able to bind calcium. The molecule can bind a maximum of four calcium ions and by undergoing post-translational modifications such as acetylation, phosphorylation, proteolytic cleavage and methylation, its functions can potentially be altered. Calmodulin is supplied as a lyophilized white powder or flocculate from 50 mM NH4HCO3 with 10 μM CaCl2. No preservatives are added. The protein content is analyzed by amino acid assay and is never less than 80 % of weighed substance. The material has been subjected to an acid treatment for minimum 30 min. The protein is derived from a single batch and is homogenous. Protein calcium binding studies on the regulation of a multitude of different protein targets; Activation of cyclic nucleotide-dependent phosphodiesterase; Co-factor/activator for kinase studies; Studies of edema factor toxin and anthrax bacteria

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