产品名称

英文名称：Azelaic acid

同义词

azelaic acid、NONANEDIOIC ACID、123-99-9、Finacea、Anchoic acid、Azelex、Lepargylic acid、1,7-Heptanedicarboxylic acid、Skinoren、1,9-Nonanedioic acid、Heptanedicarboxylic acid、n-Nonanedioic acid、Emerox 1110、Emerox 1144、azelate、acide azelaique、acidum azelaicum、Fine、杜鹃花酸、1,7-庚二甲酸

产品性质

CAS编号：123-99-9

分子式：C9H16O4

分子量：188.22

Beilstein号：1101094

EC号：204-669-1

MDL号：MFCD00004432

PubChem编号：2266

别名：杜鹃花酸|1,7-庚二甲酸

英文别名：azelaic acid|NONANEDIOIC ACID|123-99-9|Finacea|Anchoic acid|Azelex|Lepargylic acid|1,7-Heptanedicarboxylic acid|Skinoren|1,9-Nonanedioic acid|Heptanedicarboxylic acid|n-Nonanedioic acid|Emerox 1110|Emerox 1144|azelate|acide azelaique|acidum azelaicum|Fine

规格或纯度：99%

英文名称：Azelaic acid

生化机理：5α还原酶抑制剂。PPARγ激活剂。竞争性地抑制酪氨酸酶和硫氧还蛋白还原酶（K i值分别为3 mM和13μM）。细胞毒素为黑色素细胞。减少皮肤色素沉着。诱导水杨酸在植物中的积累。

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thoμght to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.An antiinflammatory compoundAzelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.An antiinflammatory compound

ALogP：1.6

PubChem SID：488179683

IUPAC Name：nonanedioic acid

INCHI：InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

InChi Key：BDJRBEYXGGNYIS-UHFFFAOYSA-N

Canonical SMILES：C(CCCC(=O)O)CCCC(=O)O

Isomeric SMILES：C(CCCC(=O)O)CCCC(=O)O

WGK Germany：1

RTECS：CM1980000

PubChem CID：2266

溶解性：Soluble in water (2.4 mg/ml at 20 °C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.

密度：0.821

敏感性：对湿度敏感

折光率：1.4303

闪点(℉)：410 °F

闪点(℃)：210 °C

沸点：286°C

熔点：109-111°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritation

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P264,P362+P364,P264+P265,P337+P317,P332+P317

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装