产品名称

英文名称：Pramipexole 2HCl Monohydrate

同义词

Pramipexole dihydrochloride monohydrate、191217-81-9、Mirapex、(S)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydrate、Pramipexole 2HCl Monohydrate、PRAMIPEXOLE HYDROCHLORIDE、Sifrol、Daquiran、Pramipexole hydrochloride hydrate、Prami、普拉克索二盐酸盐单水合物

产品性质

CAS编号：191217-81-9

分子式：C10H17N3S·2HCl·H2O

分子量：302.26

EC号：687-708-9

MDL号：MFCD02183927

PubChem编号：166589

别名：普拉克索二盐酸盐单水合物

英文别名：Pramipexole dihydrochloride monohydrate|191217-81-9|Mirapex|(S)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydrate|Pramipexole 2HCl Monohydrate|PRAMIPEXOLE HYDROCHLORIDE|Sifrol|Daquiran|Pramipexole hydrochloride hydrate|Prami

规格或纯度：≥98%(HPLC)

英文名称：Pramipexole 2HCl Monohydrate

生化机理：Pramipexole is a dopamine agonist active at D3 and D2 receptor subtypes. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.Potent dopamine receptor agonist. Active at D2S (K i = 3.9 nM), D2L (K i = 2.2 nM), D3 (K i = 0.5 nM) and D4 (K i = 5.1 nM) receptors. Inactive at D1 and D5 receptors. Novel non-ergoline dopamine receptor agonist.

应用：A non-ergoline dopamine agonist.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Pramipexole 2HCl Monohydrate 是一种部分/全部D2S， D2L， D3， D4受体激动剂，Ki为3.9， 2.2， 0.5， 5.1 nM。A non-ergoline dopamine agonist.Pramipexole 2HCl Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.A non-ergoline dopamine agonist.

IUPAC Name：(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;hydrate;dihydrochloride

INCHI：InChI=1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1

InChi Key：APVQOOKHDZVJEX-QTPLPEIMSA-N

Canonical SMILES：CCCNC1CCC2=C(C1)SC(=N2)N.O.Cl.Cl

Isomeric SMILES：CCCN[C@H]1CCC2=C(C1)SC(=N2)N.O.Cl.Cl

关联CAS：191217-81-9

PubChem CID：166589

MeSH Entry Terms：2 Amino 6 propylaminotetrahydrobenzothiazole;2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole;2-amino-6-propylaminotetrahydrobenzothiazole;4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine;6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine dihydr

溶解性：Soluble in water (61 mg/ml at 25 °C), DMSO (41 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

比旋光度：-67° (C=1,MeOH)

熔点：296-305°C

象形图：

信号词：Warning

危险声明：H412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowedH317 May cause an allergic skin reactionH336 May cause drowsiness or dizzinessH312 Harmful in contact with skinH332 Harmful if inhaledH362 May cause harm to breast-fed children

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P330,P263,P203,P301+P317,P318,P317,P319

Merck Index：7705

产品包装