产品名称

英文名称：Safinamide

同义词

DTXCID701436700、CHEBI134718、D10158、(S)-2[4-(3-fluorobenzyloxy)benzylamino] propanamide、BDBM50078694、Q2211523、SAFINAMIDE [INN]、2(S)-[4-(3-Fluorobenzyloxy) benzylamino] propionamide、NEMGRZFTLSKBAP-LBPRGKRZSA-N、(S)-2-[4-(3-fluorobenzyloxy)benzylamino]propan、沙芬酰胺

产品性质

CAS编号：133865-89-1

分子式：C17H19FN2O2

分子量：302.34

PubChem编号：131682

别名：沙芬酰胺

英文别名：DTXCID701436700|CHEBI134718|D10158|(S)-2[4-(3-fluorobenzyloxy)benzylamino] propanamide|BDBM50078694|Q2211523|SAFINAMIDE [INN]|2(S)-[4-(3-Fluorobenzyloxy) benzylamino] propionamide|NEMGRZFTLSKBAP-LBPRGKRZSA-N|(S)-2-[4-(3-fluorobenzyloxy)benzylamino]propan

规格或纯度：≥98%

英文名称：Safinamide

生化机理：Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, Safinamide is voltage-dependent sodium and calcium channel blocker. Safinamide appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：Safinamide (EMD 1195686; FCE 26743)是可逆的MAO-B抑制剂，IC50为98 nM，比对MAO-A的抑制性高5918倍。Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A.

ALogP：2.2

IUPAC Name：(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide

INCHI：InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1

InChi Key：NEMGRZFTLSKBAP-LBPRGKRZSA-N

Canonical SMILES：CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F

Isomeric SMILES：C[C@@H](C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F

PubChem CID：131682

CAS Registry No.：133865-89-1

ChEMBL Ligand：CHEMBL396778

Wikipedia：Safinamide

DrugCentral Ligand：4921

溶解性：DMSO

敏感性：对热敏感

熔点：212°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH318 Causes serious eye damageH400 Very toxic to aquatic life

预防措施声明：P273,P280,P321,P405,P501,P264,P270,P391,P330,P264+P265,P301+P316,P305+P354+P338,P317

产品包装