产品名称

英文名称：Ki8751

同义词

Ki8751、228559-41-9、Ki 8751、Ki-8751、N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea、RP6UGT29FF、1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea、1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyqui

产品性质

CAS编号：228559-41-9

分子式：C24H18F3N3O4

分子量：469.41

PubChem编号：11317348

英文别名：Ki8751|228559-41-9|Ki 8751|Ki-8751|N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea|RP6UGT29FF|1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea|1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyqui

规格或纯度：≥98%

英文名称：Ki8751

生化机理：Ki8751 is potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Ki8751 displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR). Ki8751 inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo; antiangiogenic.Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC 50 = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC 50 = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ki8751是高活性VEGFR2选择性抑制剂，IC50为0.9 nM，比对c-Kit，PDGFRα和FGFR-2的抑制性高40倍，对EGFR，HGFR和 InsR几乎无活性。A cell-permeable Flk-1 (VEGFR-2) and c-Kit inhibitorKi8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM, >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR.A cell-permeable Flk-1 (VEGFR-2) and c-Kit inhibitor

IUPAC Name：1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea

INCHI：InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)

InChi Key：LFKQSJNCVRGFCC-UHFFFAOYSA-N

Canonical SMILES：COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F

Isomeric SMILES：COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F

PubChem CID：11317348

溶解性：DMSO 47 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

密度：1.43

折光率：1.66

沸点：497.07° C at 760 mmHg

熔点：235-238°C

产品包装