产品名称

英文名称：PAC-1

同义词

PAC-1、315183-21-2、PAC 1、PAC1、Procaspase activating compound 1、UNII-9LIS8N0B2C、9LIS8N0B2C、2-(4-Benzylpiperazin-1-yl)-N-((2-hydroxy-3-prop-2-enyl-phenyl)methylideneamino)acetamide、Procaspase-activating compound 1、1-Piperazineacetic acid, 4-(phenylmethyl)-,

产品性质

CAS编号：315183-21-2

分子式：C23H28N4O2

分子量：392.49

MDL号：MFCD03302441

PubChem编号：135421197

英文别名：PAC-1|315183-21-2|PAC 1|PAC1|Procaspase activating compound 1|UNII-9LIS8N0B2C|9LIS8N0B2C|2-(4-Benzylpiperazin-1-yl)-N-((2-hydroxy-3-prop-2-enyl-phenyl)methylideneamino)acetamide|Procaspase-activating compound 1|1-Piperazineacetic acid, 4-(phenylmethyl)-,

规格或纯度：≥98%

英文名称：PAC-1

生化机理：PAC 1 is a procaspase-activating compound, which in turn produces caspase-3 (EC50 = 0.22 μM). PAC 1 also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). This compound is a proapoptotic, inducing apoptosis in both cancerous and non-cancerous cell lines. The induction of apoptosis is dependent on the concentration of procaspase-3 (IC50 values anre 0.003-1.41 and 5.02=9.98 μM, respectively).Potent caspase-3 activator (IC 50 = 220 nM). Also activates caspase-7 (IC 50 = 4.5 μM). Proapoptotic in vitro . Anticancer activity in vivo . Orally active.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PAC-1是一种有效的procaspase-3（酶原-3）激活剂，EC50为0.22 μM，是第一个已知的直接激活酶原e-3为caspase-3的小分子。A procaspase-activating compound.PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.A procaspase-activating compound.

IUPAC Name：2-(4-benzylpiperazin-1-yl)-N-[(E)-(2-hydroxy-3-prop-2-enylphenyl)methylideneamino]acetamide

INCHI：InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+

InChi Key：YQNRVGJCPCNMKT-LFVJCYFKSA-N

Canonical SMILES：C=CCC1=C(C(=CC=C1)C=NNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)O

Isomeric SMILES：C=CCC1=C(C(=CC=C1)/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3)O

WGK Germany：3

PubChem CID：135421197

CAS Registry No.：315183-21-2

Wikipedia：PAC-1

溶解性：Soluble in 1eq. HCl (75 nM), DMSO (100 mM), insoluble in water, ethanol (~5 mg/mL), DMSOPBS(PH 7.2)(13), DMF (~30 mg/ml), and 13 solution of ethanol PBS(PH 7.2) (~0.25 mg/ml).

敏感性：对光敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH400 Very toxic to aquatic life

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装