产品名称

英文名称：Pimecrolimus

同义词

D11AX15 、 CHEBI135888 、 DTXSID001024182 、 Pimecrolimus 、 SDZ-ASM 981、匹美克莫司

产品性质

CAS编号：137071-32-0

分子式：C43H68ClNO11

分子量：810.45

PubChem编号：6509979

别名：匹美克莫司

英文别名：D11AX15 | CHEBI135888 | DTXSID001024182 | Pimecrolimus | SDZ-ASM 981

规格或纯度：≥98%

英文名称：Pimecrolimus

生化机理：A macrolactam ascomycin derivative which inhibits production of pro-inflammatory cytokines by T cells and mast cells.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：Pimecrolimus (SDZ-ASM 981) 是一种有效的、非甾体和具有口服活性的钙调磷酸酶 (calcineurin) 抑制剂，Ki 值为 117 nM。Pimecrolimus 显示出抗炎活性。 Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity.

ALogP：3.8

IUPAC Name：(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(E)-1-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone

INCHI：InChI=1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1

InChi Key：KASDHRXLYQOAKZ-XDSKOBMDSA-N

Canonical SMILES：CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)Cl)C)O)C)OC)OC)C)C

Isomeric SMILES：CC[C@@H]1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@@H]([C@@H](C4)OC)Cl)/C)O)C)OC)OC)C)\C

PubChem CID：6509979

DrugBank Ligand：DB00337

CAS Registry No.：137071-32-0

ChEMBL Ligand：CHEMBL1200686

Wikipedia：Pimecrolimus

DrugCentral Ligand：2168

溶解性：DMSO 162 mg/mL Water <1 mg/mL Ethanol 162 mg/mL

敏感性：对光线敏感

象形图：

信号词：Warning

危险声明：H351 Suspected of causing cancerH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P362+P364,P330,P203,P301+P317,P318,P317,P319

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