产品名称

英文名称：Cinacalcet HCl

同义词

Cinacalcet hydrochloride、364782-34-3、Cinacalcet HCl、Sensipar、Mimpara、Regpara、(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride、AMG073 HCl、AMG-073 HCL、AMG073 hydrochloride、Cinacalcet hydrochloride [USAN]、Cinacalcet、盐酸西那卡塞、盐酸甲状旁腺激素、N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐

产品性质

CAS编号：364782-34-3

分子式：C22H22F3N·HCl

分子量：393.87

PubChem编号：156418

别名：盐酸西那卡塞|盐酸甲状旁腺激素|N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐

英文别名：Cinacalcet hydrochloride|364782-34-3|Cinacalcet HCl|Sensipar|Mimpara|Regpara|(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride|AMG073 HCl|AMG-073 HCL|AMG073 hydrochloride|Cinacalcet hydrochloride [USAN]|Cinacalcet

规格或纯度：≥99%

英文名称：Cinacalcet HCl

生化机理：AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism.Ca 2+ -sensing receptor agonist\xa0that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. Decreases levels of parathyroid hormone (PTH), increases adiponectin secretion,

应用：An allosteric activator of CaSR

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies sμggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile.An allosteric activator of CaSRCinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies suggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile.An allosteric activator of CaSR

IUPAC Name：N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride

INCHI：InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1

InChi Key：QANQWUQOEJZMLL-PKLMIRHRSA-N

Canonical SMILES：CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

Isomeric SMILES：C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

PubChem CID：156418

溶解性：Soluble in water (1 mg/ml at 25 °C), DMSO (79 mg/ml at 25 °C), ethanol (33 mg/ml at 25 °C), and methanol.

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH373 Causes damage to organs through prolonged or repeated exposureH412 Harmful to aquatic life with long lasting effectsH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH318 Causes serious eye damageH317 May cause an allergic skin reactionH312 Harmful in contact with skinH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P501,P264,P260,P270,P272,P333+P313,P362+P364,P391,P330,P264+P265,P301+P317,P305+P354+P338,P317,P337+P317,P319

产品包装