产品名称

英文名称：Aciclovir

同义词

acyclovir、Aciclovir、Acycloguanosine、59277-89-3、Zovirax、Virorax、Vipral、Wellcome-248U、Aciclovirum、9-[(2-Hydroxyethoxy)methyl]guanine、Sitavig、Zovir、2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one、Gerpevir、Hascovir、Acyclovir-side chain-2-3H、Aciclovirum、阿昔洛韦、无环鸟苷、9-[(2-羟基乙氧基)甲基]鸟嘌呤、阿昔洛维、开糖环鸟苷、羟乙氧甲鸟嘌呤、无环鸟嘌呤核苷、无环鸟嘌呤

产品性质

CAS编号：59277-89-3

分子式：C8H11N5O3

分子量：225.2

MDL号：MFCD00057880

PubChem编号：135398513

别名：阿昔洛韦|无环鸟苷|9-[(2-羟基乙氧基)甲基]鸟嘌呤|阿昔洛维|开糖环鸟苷|羟乙氧甲鸟嘌呤|无环鸟嘌呤核苷|无环鸟嘌呤

英文别名：acyclovir|Aciclovir|Acycloguanosine|59277-89-3|Zovirax|Virorax|Vipral|Wellcome-248U|Aciclovirum|9-[(2-Hydroxyethoxy)methyl]guanine|Sitavig|Zovir|2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one|Gerpevir|Hascovir|Acyclovir-side chain-2-3H|Aciclovirum

规格或纯度：≥99%

英文名称：Aciclovir

生化机理：Acyclovir is an antiviral compound that can be used to induce apoptosis in cells transfected with herpes simplex virus thymidine kinase (HSV-TK). The compound may exert inhibitory effects throμgh the alterations of the cell cycle in leukemia cells lines, such as p185BCR-ABL expressing OM9;22 cells, by synchronizing the G0/G1 phase. Formation of acycloguanosine triphosphate occurs throμgh the phosphorylation of HSV-TK and can inhibit the viral DNA polymerase. Acyclovir also has the ability to inhibit the proliferation of the fibroblast cells, NIH 3T3, transformed with v-abl or bcr-abl.Guanosine derivative, competitively inhibits viral DNA polymerase. High specificity for herpes simplex 1 and 2 (EC 50 values are 0.04 and 0.44 μM, respectively) and varicella-zoster viruses (IC 50 = 0.22 μM).

应用：An antiviral compound that can be used to induce apoptosis.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Acyclovir 是一种合成的核苷类似物，有效作用于疱疹病毒。Aciclovir is a synthetic nucleoside analogue active against herpesviruses.An antiviral compound that can be used to induce apoptosis.

PubChem SID：488202820

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488202820

IUPAC Name：2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one

INCHI：InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)

InChi Key：MKUXAQIIEYXACX-UHFFFAOYSA-N

Canonical SMILES：C1=NC2=C(N1COCCO)N=C(NC2=O)N

Isomeric SMILES：C1=NC2=C(N1COCCO)N=C(NC2=O)N

WGK Germany：2

RTECS：UP0791400

PubChem CID：135398513

Reaxy-Rn：1219402

DrugBank Ligand：DB00787

Wikipedia：Aciclovir

CAS Registry No.：59277-89-3

ChEMBL Ligand：CHEMBL184

RCSB PDB Ligand：AC2

DrugCentral Ligand：85

溶解性：Soluble in water (partly), DMSO (50 mg/ml), DMF (1 mg/ml), 1eq. HCl (50 mM), and dilute alkalies.

熔点：262°C

Merck Index：146

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装