产品名称

英文名称：Maraviroc

同义词

Maraviroc、376348-65-1、Selzentry、Celsentri、UK-427857、UK-427,857、UK 427857、MD6P741W8A、CHEMBL256907、CHEMBL584744、MVC、CHEMBL1201187、DTXSID8048949、CHEBI63608、4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octa、UK-427857、4,4-二氟-N-(1S)-3-(3-外)-3-3-甲基-5-(1-甲基乙基)-4H-1,2,4-三唑-4-基-8-氮杂双环、3.2.1 辛-8-基-1-苯基丙基 环己甲酰胺、马拉韦罗、马拉维若

产品性质

CAS编号：376348-65-1

分子式：C29H41F2N5O

分子量：513.67

EC号：609-456-0

MDL号：MFCD13188530

PubChem编号：3002977

别名：UK-427857|4,4-二氟-N-(1S)-3-(3-外)-3-3-甲基-5-(1-甲基乙基)-4H-1,2,4-三唑-4-基-8-氮杂双环|3.2.1 辛-8-基-1-苯基丙基 环己甲酰胺|马拉韦罗|马拉维若

英文别名：Maraviroc|376348-65-1|Selzentry|Celsentri|UK-427857|UK-427,857|UK 427857|MD6P741W8A|CHEMBL256907|CHEMBL584744|MVC|CHEMBL1201187|DTXSID8048949|CHEBI63608|4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octa

规格或纯度：98%

英文名称：Maraviroc

生化机理：Maraviroc (UK-427857; Selzentry; Celsentri) is a Selective CCR5 antagonist; displays potent anti-HIV-1 activity. Maraviroc (UK-427857; Selzentry; Celsentri) prevents the interaction of HIV-1 gp120 and CCR5 (IC50 = 6.4 nM), inhibiting HIV-1 entry. Maraviroc also inhibits CCL3 (MIP-1α) binding to CCR5.Potent and selective CCR5 antagonist. Blocks binding of\xa0 MIP-1 alpha (IC 50 = 3.3 nM), MIP-1 beta (IC 50 = 7.2 nM) and RANTES (IC 50 = 5.2 nM) to CCR5 in radioligand binding competition assays.

法律信息：Sold for only research purposes

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Maraviroc (UK-427857)是一种CCR5拮抗剂，作用于MIP-1α，MIP-1β和RANTES，无细胞试验中IC50分别为3.3 nM，7.2 nM和5.2 nM。Maraviroc可应用于治疗HIV感染。Maraviroc has been used as aC-C chemokine receptor type 5(CCR5-specific) inhibitor in murine monocyte/macrophage cell line J774A.1, porcine uterine luminal epithelial cells and human lung CD4+ Tcells.

ALogP：5.1

IUPAC Name：4,4-difluoro-N-[(1S)-3-[(1S,5R)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide

INCHI：InChI=1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25?,26-/m0/s1

InChi Key：GSNHKUDZZFZSJB-HLMSNRGBSA-N

Canonical SMILES：CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C

Isomeric SMILES：CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C

WGK Germany：1

关联CAS：2414315-81-2,376348-65-1

PubChem CID：3002977

MeSH Entry Terms：4,4-difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide;maraviroc;Selzentry;UK 427,857;UK 427857;UK-427,857;UK-427857;UK427,857;UK427857

Wikipedia：Maraviroc

DrugBank Ligand：DB04835

CAS Registry No.：376348-65-1

GPCRdb Ligand：maraviroc

溶解性：DMSO >30 mg/ml

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH412 Harmful to aquatic life with long lasting effects

预防措施声明：P273,P501,P260,P319

产品包装