产品名称

英文名称：JANEX-1

同义词

JANEX-1、202475-60-3、WHI-P131、jak3 inhibitor i、Janex 1、4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol、4-(6,7-dimethoxyquinazolin-4-ylamino)phenol、4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol、1J8Q49TR3I、CHEMBL405130、4-[(6,7-Dimethoxy-4-quinazolinyl)amino]ph

产品性质

CAS编号：202475-60-3

分子式：C16H15N3O3

分子量：297.31

PubChem编号：3794

英文别名：JANEX-1|202475-60-3|WHI-P131|jak3 inhibitor i|Janex 1|4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol|4-(6,7-dimethoxyquinazolin-4-ylamino)phenol|4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol|1J8Q49TR3I|CHEMBL405130|4-[(6,7-Dimethoxy-4-quinazolinyl)amino]ph

规格或纯度：98%

英文名称：JANEX-1

生化机理：Janex-1是可渗透入细胞的ATP竞争性JAK3特异性抑制剂，对JAK1，JAK2，Zap/Syk和SRC无活性。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 μM). Janex-1 has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. Janex-1 acts as a potent inhibitor of glioblastoma cell adhesion and migration and is also reported to block thrombin-induced platelet aggregation.A selective inhibitor of tyrosine kinase activity of JAK3Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 μM). Janex-1 has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. Janex-1 acts as a potent inhibitor of glioblastoma cell adhesion and migration and is also reported to block thrombin-induced platelet aggregation.A selective inhibitor of tyrosine kinase activity of JAK3

ALogP：3

IUPAC Name：4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

INCHI：InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)

InChi Key：HOZUXBLMYUPGPZ-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC

Isomeric SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC

PubChem CID：3794

溶解性：Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml).

密度：1.34

折光率：1.69

沸点：468.10° C

熔点：192.17°C

产品包装