产品名称

英文名称：Tariquidar

同义词

Tariquidar、206873-63-4、XR9576、XR 9576、N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide、N-(2-((4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)carbamoyl)-4,5-dim

产品性质

CAS编号：206873-63-4

分子式：C38H38N4O6

分子量：646.73

PubChem编号：148201

英文别名：Tariquidar|206873-63-4|XR9576|XR 9576|N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide|N-(2-((4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)carbamoyl)-4,5-dim

规格或纯度：98%

英文名称：Tariquidar

生化机理：Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrμg resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drμgs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drμg, thereby aμgmenting its cytotoxicity.

储存温度：-20°C储存

运输条件：超低温冰袋运输

ALogP：6.1

IUPAC Name：N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide

INCHI：InChI=1S/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43)

InChi Key：LGGHDPFKSSRQNS-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC

Isomeric SMILES：COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC

PubChem CID：148201

ChEMBL Ligand：CHEMBL348475

BindingDB Ligand：50075373

DrugBank Ligand：DB06240

CAS Registry No.：206873-63-4

RCSB PDB Ligand：R1H

溶解性：DMSO 129 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

熔点：>190ºC (dec.)

产品包装