产品名称

英文名称：Mizolastine

同义词

GTPL10102、MLS006010068、NCGC00181013-01、AB01566892_01、Mizolastine、MIZOLASTINE [MI]、MKC431、MKC-431、Mizolastine [INN]、DTXSID5046801、Mizolastine (JAN/INN)、Tox21_112663、J-507624、T71584、Zolim、CS-1997、2-((1-(1-(p-Fluorobenzyl)-2-benzimidazolyl)-4-piperidyl)methy、咪唑司汀

产品性质

CAS编号：108612-45-9

分子式：C24H25FN6O

分子量：432.49

MDL号：MFCD23140913

PubChem编号：65906

别名：咪唑司汀

英文别名：GTPL10102|MLS006010068|NCGC00181013-01|AB01566892_01|Mizolastine|MIZOLASTINE [MI]|MKC431|MKC-431|Mizolastine [INN]|DTXSID5046801|Mizolastine (JAN/INN)|Tox21_112663|J-507624|T71584|Zolim|CS-1997|2-((1-(1-(p-Fluorobenzyl)-2-benzimidazolyl)-4-piperidyl)methy

规格或纯度：≥98%

英文名称：Mizolastine

应用：Mizolastine是组胺H1受体拮抗剂，IC50为47 nM。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. Target Histamine H1-receptor Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. It does not prevent the actual release of histamine from mast cells, just prevents it binding to receptors. Side effects can include dry mouth and throat. Mizolastine has demonstrated antiallergic effects in animals and healthy volunteers and anti-inflammatory activity in animal models. Double-blind trials have shown mizolastine to be significantly more effective than placebo and as effective as other second generation antihistamine agents, such as loratadine or cetirizine, in the management of patients with perennial or seasonal allergic rhinitis and in patients with chronic idiopathic urticaria. Available data also sμggest that prophylactic administration of mizolastine is significantly more effective than placebo and as effective as prophylactic terfenadine in delaying the onset of symptoms of seasonal allergic rhinitis.Mizolastine是组胺H1受体拮抗剂，IC50为47 nM。Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. Target Histamine H1-receptor Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. It does not prevent the actual release of histamine from mast cells, just prevents it binding to receptors. Side effects can include dry mouth and throat. Mizolastine has demonstrated antiallergic effects in animals and healthy volunteers and anti-inflammatory activity in animal models. Double-blind trials have shown mizolastine to be significantly more effective than placebo and as effective as other second generation antihistamine agents, such as loratadine or cetirizine, in the management of patients with perennial or seasonal allergic rhinitis and in patients with chronic idiopathic urticaria. Available data also suggest that prophylactic administration of mizolastine is significantly more effective than placebo and as effective as prophylactic terfenadine in delaying the onset of symptoms of seasonal allergic rhinitis.Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

ALogP：3.2

IUPAC Name：2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methylamino]-1H-pyrimidin-6-one

INCHI：InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)

InChi Key：PVLJETXTTWAYEW-UHFFFAOYSA-N

Canonical SMILES：CN(C1CCN(CC1)C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)C5=NC=CC(=O)N5

Isomeric SMILES：CN(C1CCN(CC1)C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)C5=NC=CC(=O)N5

PubChem CID：65906

CAS Registry No.：108612-45-9

ChEMBL Ligand：CHEMBL94454

BindingDB Ligand：22877

DrugCentral Ligand：1824

GPCRdb Ligand：mizolastine

溶解性：DMSO <1 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

熔点：224 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaled

预防措施声明：P261,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P362+P364,P330,P301+P317,P317

Merck Index：6221

产品包装