产品名称

英文名称：Linagliptin

同义词

BI 1356、8-((3R)-3-AMINOPIPERIDIN-1-YL)-7-(BUT-2-YN-1-YL)-3-METHYL-1-((4-METHYLQUINAZOLIN-2-YL)METHYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE、A10BH05、2-Imino-4-oxothiazolidine-5-acetic acid、(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazol、利拉利汀

产品性质

CAS编号：668270-12-0

分子式：C25H28N8O2

分子量：472.54

PubChem编号：10096344

别名：利拉利汀

英文别名：BI 1356|8-((3R)-3-AMINOPIPERIDIN-1-YL)-7-(BUT-2-YN-1-YL)-3-METHYL-1-((4-METHYLQUINAZOLIN-2-YL)METHYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE|A10BH05|2-Imino-4-oxothiazolidine-5-acetic acid|(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazol

规格或纯度：≥99%

英文名称：Linagliptin

生化机理：inagliptin is a highly potent, selective CD26 (DPP-4) inhibitor with IC50 of 1 nM.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：10mg、50mg、100mg卖完停产，不再备货

产品介绍：Linagliptin是一种高效的，选择性的DPP-4抑制剂，IC50为1 nM。A highly potent, selective CD26 (DPP-4) inhibitor.Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.A highly potent, selective CD26 (DPP-4) inhibitor.

ALogP：1.9

IUPAC Name：8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione

INCHI：InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1

InChi Key：LTXREWYXXSTFRX-QGZVFWFLSA-N

Canonical SMILES：CC#CCN1C2=C(N=C1N3CCCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

Isomeric SMILES：CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

PubChem CID：10096344

ChEMBL Ligand：CHEMBL237500

ChEBI：CHEBI68610

DrugBank Ligand：DB08882

CAS Registry No.：668270-12-0

Wikipedia：Linagliptin

RCSB PDB Ligand：356

PEP：linagliptin

DrugCentral Ligand：4175

溶解性：Soluble in DMSO (17 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (1 mg/ml at 25 °C), 0.5% hyroxyethylcellulose (30 mg/ml at 25 °C), and methanol.

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装