产品名称

英文名称：2-Iminobiotin

同义词

2-iminobiotin、13395-35-2、Guanidinobiotin、5-[(3aS,4S,6aR)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid、2-IMINOBIOTIN HYDROBROMIDE、5-((3aR,6S,6aS)-2-Amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl)pentanoic acid、HXH71NR、六氢-2-亚氨基-1H-噻吩、六氢-2-亚氨基-1H-噻吩 [3,4-d] 咪唑-4-戊酸、胍基生物素

产品性质

CAS编号：13395-35-2

分子式：C10H17N3O2S

分子量：243.33

Beilstein号：18952

MDL号：MFCD00066150

PubChem编号：128878

别名：六氢-2-亚氨基-1H-噻吩|六氢-2-亚氨基-1H-噻吩 [3,4-d] 咪唑-4-戊酸|胍基生物素

英文别名：2-iminobiotin|13395-35-2|Guanidinobiotin|5-[(3aS,4S,6aR)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid|2-IMINOBIOTIN HYDROBROMIDE|5-((3aR,6S,6aS)-2-Amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl)pentanoic acid|HXH71NR

规格或纯度：98%

英文名称：2-Iminobiotin

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：2-亚氨基生物素是生物素的环状胍基类似物，在高 pH (> 9) 下对亲和素具有高亲和力，在低 pH (< 6) 下具有低亲和力。亚氨基生物素化的蛋白质选择性地包含在 pH 9-11 的亲和素柱内，可在 pH 4 洗脱或加入生物素洗脱。该技术可用于研究细胞表面蛋白，通过标记和选择性地从完整的人红细胞表面回收高碘酸盐敏感的成分。2-亚氨基生物素通过其胍基可逆性抑制 NOS（一氧化氮合酶）。它抑制 NO 的生物合成，了解这类重要酶的结合位点相互作用可能很重要。NOS 氧化 L-精氨酸的胍基氮生成一氧化氮和 L-瓜氨酸。2-Iminobiotin is a cyclic guanidino analog of biotin that has high affinity for avidin at high pH (>9) and low affinity at low pH (<6). The proteins that are iminobiotinylated are selectively contained within the avidin column at pH 9 to 11 and may be eluted at pH 4 or by the addition of biotin. This technique may be very useful in the study of cell surface proteins by labeling and selectively recovering the components that are periodate-sensitive from intact human erythrocyte surface.2-Iminobiotin reversibly inhibits NOS (nitric oxide synthases) via its guanidino group. It inhibits NO biosynthesis and may be important to understand the binding-site interactions for this important class of enzymes. NOS oxidizes the guanidino-nitrogen of L-arginine to produce nitric oxide and L-citrullineA reversible inhibitor of mouse NOS2 (iNOS) and rat NOS1 (nNOS)

IUPAC Name：5-[(3aS,4S,6aR)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid

INCHI：InChI=1S/C10H17N3O2S/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13)/t6-,7-,9-/m0/s1

InChi Key：WWVANQJRLPIHNS-ZKWXMUAHSA-N

Canonical SMILES：C1C2C(C(S1)CCCCC(=O)O)N=C(N2)N

Isomeric SMILES：C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)N=C(N2)N

WGK Germany：3

PubChem CID：128878

溶解性：Soluble in 0.1N hydrochloric acid.

密度：1.6

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装