产品名称

英文名称：Oligomycin

同义词

Oligomycin a, b, c mixture、Oligomycin

产品性质

CAS编号：1404-19-9

分子式：C45H74O11

分子量：791.07(for Oligomycin A)

Beilstein号：7615308

EC号：MFCD01779388

MDL号：MFCD00065705

PubChem编号：5281899

别名：Oligomycin

英文别名：Oligomycin a, b, c mixture

规格或纯度：92%

英文名称：Oligomycin

生化机理：Macrolide antibiotic; inhibits mitochondrial ATPase and phosphoryl group transfer.ATP synthase inhibitor. Blocks the proton channel (F o subunit). Macrolide antibiotic.

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A ,B , and C .Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levelsA specific inhibitor of the mitochondrial ATP-synthase.Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A ,B , and C .Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levelsA specific inhibitor of the mitochondrial ATP-synthase.

IUPAC Name：(1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27S,28R,29S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione

INCHI：InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1

InChi Key：MNULEGDCPYONBU-WMBHJXFZSA-N

Canonical SMILES：CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C

Isomeric SMILES：CC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C

WGK Germany：3

PubChem CID：5281899

溶解性：Soluble in EtOH, acetone (50 mg/ml), DMSO (300 mg/ml), ethanol, and methanol. Insoluble in water

敏感性：对湿度敏感;对光敏感

熔点：84-100°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH302 Harmful if swallowedH370 Causes damage to organs

预防措施声明：P321,P405,P501,P264,P260,P270,P330,P301+P316,P301+P317,P308+P316

个人防护装备：dust mask type N95 (US),Eyeshields,Faceshields,Gloves

产品包装