产品名称

英文名称：Laropiprant

同义词

Laropiprant [USANINNBAN]、2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methanesulfonyl-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic acid、(-)-((3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta(b)indol-3-yl)acetic acid、Laropip、拉罗皮兰

产品性质

CAS编号：571170-77-9

分子式：C21H19ClFNO4S

分子量：435.9

PubChem编号：9867642

别名：拉罗皮兰

英文别名：Laropiprant [USANINNBAN]|2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methanesulfonyl-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic acid|(-)-((3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta(b)indol-3-yl)acetic acid|Laropip

规格或纯度：≥99%

英文名称：Laropiprant

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Laropiprant(MK 0524)是高活性DP1受体拮抗剂，Ki为 0.57 nM，对DP2受体的Ki为750nM。Laropiprant(MK 0524) is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM; exhibits >1,000 fold selectivity over DP2 receptor (Ki=0.75 uM).

ALogP：3.5

IUPAC Name：2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid

INCHI：InChI=1S/C21H19ClFNO4S/c1-29(27,28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12/h2-3,5-6,9-10,13H,4,7-8,11H2,1H3,(H,25,26)/t13-/m1/s1

InChi Key：NXFFJDQHYLNEJK-CYBMUJFWSA-N

Canonical SMILES：CS(=O)(=O)C1=CC(=CC2=C1N(C3=C2CCC3CC(=O)O)CC4=CC=C(C=C4)Cl)F

Isomeric SMILES：CS(=O)(=O)C1=CC(=CC2=C1N(C3=C2CC[C@@H]3CC(=O)O)CC4=CC=C(C=C4)Cl)F

PubChem CID：9867642

CAS Registry No.：571170-77-9

ChEMBL Ligand：CHEMBL426559

Wikipedia：Laropiprant

DrugCentral Ligand：4326

GPCRdb Ligand：laropiprant

溶解性：DMSO

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装