产品名称

英文名称：AS-605240

同义词

AS-605240、648450-29-7、AS605240、5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE、AS 605240、(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione、PI 3-Kg inhibitor、(Z)-5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione、CHEMBL568150、1287651-14-2、(5、5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮

产品性质

CAS编号：648450-29-7

分子式：C12H7N3O2S

分子量：257.27

MDL号：MFCD11100415

PubChem编号：5289247

别名：5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮

英文别名：AS-605240|648450-29-7|AS605240|5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE|AS 605240|(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione|PI 3-Kg inhibitor|(Z)-5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione|CHEMBL568150|1287651-14-2|(5

规格或纯度：≥98%

英文名称：AS-605240

生化机理：AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. AS-605240 suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AS-605240是PI3Kγ选择性抑制剂，IC50为8 nM。比对PI3Kδ，PI3Kβ和PI3Kα的抑制性强30倍和7.5倍。AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα

IUPAC Name：(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

INCHI：InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-

InChi Key：SQWZFLMPDUSYGV-POHAHGRESA-N

Canonical SMILES：C1=CC2=NC=CN=C2C=C1C=C3C(=O)NC(=O)S3

Isomeric SMILES：C1=CC2=NC=CN=C2C=C1/C=C\3/C(=O)NC(=O)S3

WGK Germany：3

PubChem CID：5289247

DrugBank Ligand：DB04769

ChEMBL Ligand：CHEMBL568150

CAS Registry No.：648450-29-7

RCSB PDB Ligand：QYT

溶解性：DMSO 0.4 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装