产品名称

英文名称：Nitazoxanide

同义词

NITAZOXANIDE、55981-09-4、Alinia、Nitazoxanida、2-((5-nitrothiazol-2-yl)carbamoyl)phenyl acetate、Nitazoxamide、Nitazoxanidum、Daxon、Nitazoxanidum [INN-Latin]、Nitazoxanida [INN-Spanish]、2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate、Benzamide, 2-(acetylox、NTZ、硝唑尼特、2-(乙酰氧基)-N-(5-硝基-2-噻唑基)苯甲酰胺、2-乙酸基-N-(5-硝基-2-噻唑基)苯甲酰胺

产品性质

CAS编号：55981-09-4

分子式：C12H9N3O5S

分子量：307.28

MDL号：MFCD00416599

PubChem编号：41684

别名：NTZ|硝唑尼特|2-(乙酰氧基)-N-(5-硝基-2-噻唑基)苯甲酰胺|2-乙酸基-N-(5-硝基-2-噻唑基)苯甲酰胺

英文别名：NITAZOXANIDE|55981-09-4|Alinia|Nitazoxanida|2-((5-nitrothiazol-2-yl)carbamoyl)phenyl acetate|Nitazoxamide|Nitazoxanidum|Daxon|Nitazoxanidum [INN-Latin]|Nitazoxanida [INN-Spanish]|2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate|Benzamide, 2-(acetylox

规格或纯度：≥98%

英文名称：Nitazoxanide

生化机理：硝唑尼特是丙酮酸铁氧还蛋白氧化还原酶(PFOR)的抑制剂。最近发现显示，这种抗菌剂可杀死非复制型和复制型分枝杆菌。 FDA批准了抗寄生虫药（2002 年）。最近的工作(C & EN Sept. 14, 2009, p. 28) 强调NTZ可杀死非复制和复制型TB细菌，且未发现明显耐药性。广谱抗寄生虫，抗菌剂。抗炎，低毒。非竞争性抑制丙酮酸氧化还原酶。在体外和体内具有活性。

应用：Nitazoxanide has been used · to test its anti-viral activity against chikungunya virus · as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines · to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Nitazoxanide是一种人工合成的nitrothiazolyl-salicylamide衍生物，是一种抗原虫剂(作用于犬流感病毒，IC50为0.17 到0.21 μM)。Nitazoxanide has been used· to test its anti-viral activity against chikungunya virus· as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines· to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cellsNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)Nitazoxanide has been used· to test its anti-viral activity against chikungunya virus· as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines· to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells

ALogP：2

IUPAC Name：[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

INCHI：InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

InChi Key：YQNQNVDNTFHQSW-UHFFFAOYSA-N

Canonical SMILES：CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]

Isomeric SMILES：CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]

WGK Germany：3

PubChem CID：41684

溶解性：DMSO ≥ 100 mg/mL (325.44 mM)

敏感性：对热敏感

熔点：198.0 - 202.0 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

Merck Index：6567

产品包装