产品名称

英文名称：Wortmannin

同义词

wortmannin、19545-26-7、Wartmannin、KY 12420、SL-2052、Antibiotic SL-2052、NSC221019、XVA4O219QW、KY-12420、MLS002703028、CHEMBL428496、CHEBI52289、NSC-627609、(1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H、渥曼青霉素、抗生素SL-2052

产品性质

CAS编号：19545-26-7

分子式：C23H24O8

分子量：428.43

Beilstein号：67676

MDL号：MFCD00133927

PubChem编号：312145

别名：渥曼青霉素|抗生素SL-2052

英文别名：wortmannin|19545-26-7|Wartmannin|KY 12420|SL-2052|Antibiotic SL-2052|NSC221019|XVA4O219QW|KY-12420|MLS002703028|CHEMBL428496|CHEBI52289|NSC-627609|(1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H

规格或纯度：98%

英文名称：Wortmannin

生化机理：Wortmannin, a fungal metabolite, is a potent and selective inhibitor of PI 3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin displays a similar potency in vitro for the class I, II, and III PI 3-kinase members, althoμgh it can also inhibit other PI 3-kinase-related enzymes such as FRAP (mTOR), DNA-PKCS, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI 3-kinase. The half-life of Wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI 3-kinase. Wortmannin is an inhibitor of Fnk and Plk.Potent, selective and cell-permeable inhibitor of phosphatidylinositol-3-kinase (PI3-kinase) (IC 50 ~ 3 nM)

应用：A fungal metabolite which inhibits Pl3-kinase

来源：from Penicillium) wortmannii

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Wortmannin是一种PI3K抑制剂，IC50为3 nM，抑制自噬体的形成，也有效抑制DNA-PK/ATM，IC50分别为16 nM和150 nM。A fungal metabolite which inhibits Pl3-kinaseWortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.A fungal metabolite which inhibits Pl3-kinase

IUPAC Name：[(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate

INCHI：InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

InChi Key：QDLHCMPXEPAAMD-QAIWCSMKSA-N

Canonical SMILES：CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C

Isomeric SMILES：CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C

WGK Germany：3

RTECS：CB9641000

PubChem CID：312145

UN Number：3462

DrugBank Ligand：DB08059

ChEMBL Ligand：CHEMBL428496

ChEBI：CHEBI52289

CAS Registry No.：19545-26-7

Wikipedia：Wortmannin

RCSB PDB Ligand：KWT

Reactome Reaction：R-HSA-2400009

Reactome Drug：R-ALL-2399848

溶解性：Soluble in DMSO (50 mg/ml), ethanol (25 mg/ml), methanol, 18 DMSOPBS(pH 7.2) (~0.1 mg/ml), and DMF (~14 mg/ml).

密度：1.39

敏感性：对热、湿度和光线敏感

熔点：237 °C

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowedH310 Fatal in contact with skinH330 Fatal if inhaled

预防措施声明：P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P270,P304+P340,P403+P233,P330,P262,P320,P361+P364,P301+P316,P316

Merck Index：10053

个人防护装备：Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

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