产品名称

英文名称：PHA-665752

同义词

PHA-665752、477575-56-7、PHA 665752、PHA665752、TCMDC-125885、UNII-0VXU5T5R3J、(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE、0VXU5

产品性质

CAS编号：477575-56-7

分子式：C32H34Cl2N4O4S

分子量：641.61

PubChem编号：10461815

英文别名：PHA-665752|477575-56-7|PHA 665752|PHA665752|TCMDC-125885|UNII-0VXU5T5R3J|(2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE|0VXU5

规格或纯度：98%

英文名称：PHA-665752

生化机理：PHA-665752 is potent, selective and ATP-competitive inhibitor of MET kinase. (IC50 values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively and > 10000 nM for IGF-IR, PDGFR, AURORA2, PKA, PKBα, p38α, MK2 and MK3). Antitumor agent; PHA-665752 inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.Potent, selective, ATP-competitive c-Met inhibitor (K i = 4 nM; IC 50 = 9 nM).\xa0Exhibits >50- fold selectivity for c- Met over a panel of tyrosine and serine/threonine kinases. Antitumor agent;

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PHA-665752 hydrate has been used as a c-Met inhibitor to study its effects on oxidative stress in human mammary epithelial MCF10A cells with extra centrosomes to study its effects on the clonogenicity of T-cell specific transcription factor/ lymphoid enhancer-binding factor-1 (TCF/LEF-1) responsive promoter to drive expression of green fluorescent protein (TOP-GFP) cancer stem cell (CSC) cultures to study its inhibitory effects on melanoma cell lines

IUPAC Name：(3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one

INCHI：InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1

InChi Key：OYONTEXKYJZFHA-SSHUPFPWSA-N

Canonical SMILES：CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

Isomeric SMILES：CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

PubChem CID：10461815

CAS Registry No.：477575-56-7

DiscoveRx TREEspot：PHA-665752|

ChEMBL Ligand：CHEMBL450786

溶解性：DMSO 128 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装