产品名称

英文名称：Bardoxolone

同义词

Bardoxolone、CDDO、218600-44-3、RTA 401、RTA-401、(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid、2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid、CDDO(Bardoxolone

产品性质

CAS编号：218600-44-3

分子式：C31H41NO4

分子量：491.66

PubChem编号：400010

英文别名：Bardoxolone|CDDO|218600-44-3|RTA 401|RTA-401|(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid|2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid|CDDO(Bardoxolone

规格或纯度：≥98%

英文名称：Bardoxolone

生化机理：Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2, an important biological target that controls the production of many of the body's antioxidant and detoxification enzymes. Because oxidative stress and inflammation occur throμghout the course of chronic kidney disease (CKD) and are known to contribute to loss of kidney function, agents that activate the Nrf2 pathway in patients with CKD may provide a novel method for preserving or improving kidney function. Bardoxolone methyl is currently being investigated as a potential oral once-a-day treatment for CKD.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Bardoxolone(RTA 402)是抗氧化炎症调节剂（AIM）的先导化合物，此类AIM是转录因子Nrf2诱导剂。Bardoxolone(RTA 402) is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2.

IUPAC Name：(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid

INCHI：InChI=1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22-28(5)15-18(17-32)24(34)27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36)/t19-,21-,23-,28-,29+,30+,31-/m0/s1

InChi Key：TXGZJQLMVSIZEI-UQMAOPSPSA-N

Canonical SMILES：CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)O)C

Isomeric SMILES：C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)O

PubChem CID：400010

ChEMBL Ligand：CHEMBL1093059

CAS Registry No.：218600-44-3

Wikipedia：Bardoxolone

溶解性：DMSO

产品包装