产品名称

英文名称：MK-2206 2HCl

同义词

1032350-13-2、MK-2206 dihydrochloride、MK-2206 2HCl、MK2206、8-(4-(1-Aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride、8-[4-(1-AMINOCYCLOBUTYL)PHENYL]-9-PHENYL-1,2,4-TRIAZOLO[3,4-F][1,6]NAPHTHYRIDIN-3(2H)-ONE D

产品性质

CAS编号：1032350-13-2

分子式：C25H21N5O·2HCl

分子量：480.39

PubChem编号：46930998

英文别名：1032350-13-2|MK-2206 dihydrochloride|MK-2206 2HCl|MK2206|8-(4-(1-Aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride|8-[4-(1-AMINOCYCLOBUTYL)PHENYL]-9-PHENYL-1,2,4-TRIAZOLO[3,4-F][1,6]NAPHTHYRIDIN-3(2H)-ONE D

规格或纯度：≥98%

英文名称：MK-2206 2HCl

生化机理：MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2, and Akt3 with IC50 values of 8 nM, 12 nM and 65 nM, respectively. MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells

应用：A highly selective pan-Akt inhibitor activated by the pleckstrin homology domain

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：MK-2206 2HCl是一种高度选择性的Akt1/2/3抑制剂，IC50分别为8 nM/12 nM/65 nM；对250种其他蛋白激酶没有抑制活性。A highly selective pan-Akt inhibitor activated by the pleckstrin homology domainMK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively; no inhibitory activities against 250 other protein kinases observed.A highly selective pan-Akt inhibitor activated by the pleckstrin homology domain

IUPAC Name：8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one;dihydrochloride

INCHI：InChI=1S/C25H21N5O.2ClH/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31;;/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31);2*1H

InChi Key：HWUHTJIKQZZBRA-UHFFFAOYSA-N

Canonical SMILES：C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl

Isomeric SMILES：C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl

PubChem CID：46930998

ChEBI：CHEBI67271

CAS Registry No.：1032350-13-2

ChEMBL Ligand：CHEMBL1079175

Reactome Reaction：R-HSA-2400010

Reactome Drug：R-ALL-2399927

溶解性：Soluble in DMSO (≥92 mg/ml), water (≥92 mg/ml), ethanol (≥1.8 mg/ml), and methanol.

敏感性：对湿度敏感

熔点：>225°C

产品包装