产品名称

英文名称：PD153035

同义词

153436-54-5、N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine、PD153035、PD-153035、pd 153035、4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE、SU-5271、NSC-669364、AG-1517、4-(3-bromophenylamino)-6,7-dimethoxyquinazoline、WHI-P-79、TC62B68RSL、(3-Bromophenyl)(6,7-dimet

产品性质

CAS编号：153436-54-5

分子式：C16H14BrN3O2

分子量：360.21

PubChem编号：4705

英文别名：153436-54-5|N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine|PD153035|PD-153035|pd 153035|4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE|SU-5271|NSC-669364|AG-1517|4-(3-bromophenylamino)-6,7-dimethoxyquinazoline|WHI-P-79|TC62B68RSL|(3-Bromophenyl)(6,7-dimet

规格或纯度：≥98%

英文名称：PD153035

生化机理：PD 153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of the EGFR (epidermal growth factor receptor; IC50 = 25 pM; Kι = 6 pM). PD 153035 rapidly suppresses auto-phosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. PD 153035 also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation.Highly potent, selective EGFR tyrosine kinase inhibitor (K i value = 6 pM). Active in vitro and in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PD153035(ZM 252868; AG 1517)是高活性EGFR选择性抑制剂，Ki和IC50分别为5.2 pM和29 pM，而对PGDFR，FGFR，CSF-1，InsR和Src活性极低。An extremely potent and specific inhibitor of EGFR tyrosine kinase activity.PD153035(ZM 252868; AG 1517) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect against PGDFR, FGFR, CSF-1, InsR and Src.An extremely potent and specific inhibitor of EGFR tyrosine kinase activity.

IUPAC Name：N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine

INCHI：InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

InChi Key：LSPANGZZENHZNJ-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC

Isomeric SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC

PubChem CID：4705

溶解性：Soluble in DMSO (5 mg/ml).

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH318 Causes serious eye damage

预防措施声明：P280,P321,P405,P501,P264,P270,P330,P264+P265,P301+P316,P305+P354+P338,P317

产品包装