产品名称

英文名称：AG14361

同义词

AG14361、328543-09-5、AG-14361、AG 14361、Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-、CHEMBL65892、1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one、48N0U0K50I、AG-014361、I

产品性质

CAS编号：328543-09-5

分子式：C19H20N4O

分子量：320.4

PubChem编号：9840076

英文别名：AG14361|328543-09-5|AG-14361|AG 14361|Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-|CHEMBL65892|1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one|48N0U0K50I|AG-014361|I

规格或纯度：≥98%

英文名称：AG14361

生化机理：AG14361 is at least 1000-fold more potent than the benzamides.AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy of mice bearing LoVo xenografts. AG14361 statistically significantly increases blood flow in xenografts and thus potentially increases drμg delivery to tumor xenografts.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg、10mg卖完停产，不再备货

产品介绍：AG14361是PARP1抑制剂，Ki<5 nM，比苯甲酰胺的抑制性强1000倍。AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides.

IUPAC Name：2-[4-[(dimethylamino)methyl]phenyl]-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-9-one

INCHI：InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)

InChi Key：SEKJSSBJKFLZIT-UHFFFAOYSA-N

Canonical SMILES：CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O

Isomeric SMILES：CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O

PubChem CID：9840076

CAS Registry No.：328543-09-5

ChEMBL Ligand：CHEMBL65892

溶解性：DMSO ≥20mg/mL Water <1.2mg/mL Ethanol ≥11mg/mL

产品包装