产品名称

英文名称：BMS-707035

同义词

BMS-707035、729607-74-3、BMS707035、BMS 707035、HIV Integrase Inhibitor、7PR4P7YOKT、2-(1,1-dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide、2-(1,1-dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydr

产品性质

CAS编号：729607-74-3

分子式：C17H19FN4O5S

分子量：410.42

PubChem编号：54682040

英文别名：BMS-707035|729607-74-3|BMS707035|BMS 707035|HIV Integrase Inhibitor|7PR4P7YOKT|2-(1,1-dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide|2-(1,1-dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydr

规格或纯度：≥98%

英文名称：BMS-707035

生化机理：BMS-707035 is an HIV-1 integrase (IN) inhibitor. BMS-707035 was scheduled to be evaluated in a Phase II study to assess the antiretroviral activity, safety, pharmacodynamics, and pharmacokinetics in 50 HIV-infected subjects using a 10-day randomized, double-blind, placebo-controlled, ascending multiple-dose study design.Potent, specific, reversible, pyrimidine carboxamide HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity in vitro (IC 50 = 15 nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.

ALogP：1

IUPAC Name：2-(1,1-dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxopyrimidine-4-carboxamide

INCHI：InChI=1S/C17H19FN4O5S/c1-21-16(25)14(23)13(15(24)19-10-11-4-6-12(18)7-5-11)20-17(21)22-8-2-3-9-28(22,26)27/h4-7,23H,2-3,8-10H2,1H3,(H,19,24)

InChi Key：VNIWZCGZPBJWBI-UHFFFAOYSA-N

Canonical SMILES：CN1C(=O)C(=C(N=C1N2CCCCS2(=O)=O)C(=O)NCC3=CC=C(C=C3)F)O

Isomeric SMILES：CN1C(=O)C(=C(N=C1N2CCCCS2(=O)=O)C(=O)NCC3=CC=C(C=C3)F)O

PubChem CID：54682040

溶解性：DMSO 38 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装