产品名称

英文名称：EMD 1214063

同义词

Tepotinib、MSC2156119、Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-、TEPOTINIB [WHO-DD]、Tepotinib(EMD-1214063)、MSC2156119J、AHYMHWXQRWRBKT-UHFFFAOYSA-N、compound 22 [PMID 25736998]、特泊替尼

产品性质

CAS编号：1100598-32-0

分子式：C29H28N6O2

分子量：492.57

PubChem编号：25171648

别名：特泊替尼

英文别名：Tepotinib|MSC2156119|Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-|TEPOTINIB [WHO-DD]|Tepotinib(EMD-1214063)|MSC2156119J|AHYMHWXQRWRBKT-UHFFFAOYSA-N|compound 22 [PMID 25736998]|

规格或纯度：98%

英文名称：EMD 1214063

生化机理：EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor EMD-1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types; this protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Tepotinib (EMD 1214063, MSC2156119) 是一种有效的，选择性的c-Met抑制剂，IC50为4 nM，作用于c-Met比作用于IRAK4， TrkA， Axl， IRAK1和Mer选择性高200倍以上。Tepotinib 可诱导自噬。Phase 1。

ALogP：3.4

IUPAC Name：3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile

INCHI：InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3

InChi Key：AHYMHWXQRWRBKT-UHFFFAOYSA-N

Canonical SMILES：CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N

Isomeric SMILES：CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N

PubChem CID：25171648

CAS Registry No.：1100598-32-0

RCSB PDB Ligand：3E8

DrugCentral Ligand：5424

溶解性：DMSO mg/mL Water mg/mL Ethanol mg/mL；溶于DMSO，最高浓度 (mg/mL)17, 最高浓度(mM)34.51（50℃水浴加热）；溶于Ethanol，最高浓度 (mg/mL)6, 最高浓度(mM)12.18；不溶于水

产品包装