产品名称

英文名称：U0126-EtOH

同义词

U0126-EtOH、1173097-76-1、U0126 Ethanol、U0126.EtOH、(2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile compound with ethanol (11)、(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile;ethanol、2,3-Bis(amino((2-aminophenyl)thi

产品性质

CAS编号：1173097-76-1

分子式：C18H16N6S2.C2H6O

分子量：426.56

PubChem编号：16220066

英文别名：U0126-EtOH|1173097-76-1|U0126 Ethanol|U0126.EtOH|(2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile compound with ethanol (11)|(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile;ethanol|2,3-Bis(amino((2-aminophenyl)thi

规格或纯度：≥97%

英文名称：U0126-EtOH

生化机理：U0126-EtOH functionally antagonizes AP- 1 transcriptional activity and blocks the production of a variety of cytokines and metalloproteinases involved in the inflammatory response. U0126-EtOH inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs without effect on IL-2-induced proliferation by down-regulating IL-2 mRNA levels . A recent study shows that U0126-EtOH antagonizes resveratrol-induced apoptosis in castration-resistant human prostate cancer C4-2 cells, inhibits mitochondrial function and shifts cells to aerobic glycolysis independently of MEK .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：500mg卖完停产，不再备货

产品介绍：U0126-EtOH(U-0126)是MEK1和2选择性抑制剂，IC50分别为70nM和60nM，对ΔN3-S218E/S222D MEK的亲和力比PD098059强100倍。U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059.

IUPAC Name：(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile;ethanol

INCHI：InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+;

InChi Key：CFQULUVMLGZVAF-OYJDLGDISA-N

Canonical SMILES：CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N

Isomeric SMILES：CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N

PubChem CID：16220066

溶解性：DMSO ≥83mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

产品包装