产品名称

英文名称：Dorsomorphin 2HCl

同义词

BML-275;6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (12);Compound C dihydrochloride; BML275 dihydrochloride; BML 275 dihydrochloride、BML-275

产品性质

CAS编号：1219168-18-9

分子式：C24H25N5O·2HCl

分子量：472.41

PubChem编号：49761481

别名：BML-275

英文别名：BML-275;6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (12);Compound C dihydrochloride; BML275 dihydrochloride; BML 275 dihydrochloride

规格或纯度：≥98%

英文名称：Dorsomorphin 2HCl

生化机理：Dorsomorphin dihydrochloride has been shown to act as a potent and selective inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM), induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6). This compound is not thoμght to show significant activity on structurally related kinases. Dorsomorphin, Free Base, is also available .Potent, selective, reversible AMP-kinase inhibitor (K i = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expre

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：Dorsomorphin 2HCl是一种有效的，可逆的AMPK选择性抑制剂，Ki为109 nM，对一些结构相关的激酶，包括ZAPK， SYK， PKCθ， PKA和JAK3没有显著的抑制作用。同时抑制了BMP一型受体作用。A potent and selective AMPK inhibitor.Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits BMP type I receptor.A potent and selective AMPK inhibitor.

IUPAC Name：6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride

INCHI：InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H

InChi Key：RJDVIJJQKMGPMV-UHFFFAOYSA-N

Canonical SMILES：C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

Isomeric SMILES：C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

PubChem CID：49761481

溶解性：Soluble in water (100 mM), and DMSO (20 mM).

产品包装