产品名称

英文名称：MBX-2982

同义词

MBX-2982、1037792-44-1、4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)thiazole、MBX2982、2-[1-(5-ethylpyrimidin-2-yl)-4-piperidyl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]thiazole、B5TRY67L51、CHEMBL3260505、2-[1-(5-ethylpyrimidi

产品性质

CAS编号：1037792-44-1

分子式：C22H24N8OS

分子量：448.54

PubChem编号：25025505

英文别名：MBX-2982|1037792-44-1|4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)thiazole|MBX2982|2-[1-(5-ethylpyrimidin-2-yl)-4-piperidyl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]thiazole|B5TRY67L51|CHEMBL3260505|2-[1-(5-ethylpyrimidi

规格或纯度：≥98%

英文名称：MBX-2982

生化机理：MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally-active GPR119 agonist that functions throμgh a unique dual mechanism of action. First, it acts directly on the beta cell to increase insulin secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：MBX-2982是口服活性GPR119选择性激动剂。MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes.

ALogP：3.6

IUPAC Name：2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole

INCHI：InChI=1S/C22H24N8OS/c1-2-16-11-23-22(24-12-16)29-9-7-17(8-10-29)21-26-18(14-32-21)13-31-20-5-3-19(4-6-20)30-15-25-27-28-30/h3-6,11-12,14-15,17H,2,7-10,13H2,1H3

InChi Key：NFTMKHWBOINJGM-UHFFFAOYSA-N

Canonical SMILES：CCC1=CN=C(N=C1)N2CCC(CC2)C3=NC(=CS3)COC4=CC=C(C=C4)N5C=NN=N5

Isomeric SMILES：CCC1=CN=C(N=C1)N2CCC(CC2)C3=NC(=CS3)COC4=CC=C(C=C4)N5C=NN=N5

PubChem CID：25025505

CAS Registry No.：1037792-44-1

ChEMBL Ligand：CHEMBL3260505

BindingDB Ligand：50013909

GPCRdb Ligand：MBX-2982

RCSB PDB Ligand：8VP

溶解性：DMSO

产品包装