产品名称

英文名称：2-Cl-IB-MECA

同义词

2-Cl-IB-Meca、163042-96-4、Namodenoson、Chloro-IB-MECA、Cl-IB-MECA、CF-102、CF102、C-Ibza-MU、(2S,3S,4R,5R)-5-(2-Chloro-6-((3-iodobenzyl)amino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrofuran-2-carboxamide、CI-IB-MECA、Namodenoson [USAN]、2Cl-IB-MECA、2-Chloro-N、氯-IB-MECA、2-氯-N6-(3-碘苄基)腺苷-5'-N-甲基脲酰胺、腺苷 A₃ 受体激动剂

产品性质

CAS编号：163042-96-4

分子式：C18H18ClIN6O4

分子量：544.73

MDL号：MFCD01861178

PubChem编号：3035850

别名：氯-IB-MECA|2-氯-N6-(3-碘苄基)腺苷-5'-N-甲基脲酰胺|腺苷 A₃ 受体激动剂

英文别名：2-Cl-IB-Meca|163042-96-4|Namodenoson|Chloro-IB-MECA|Cl-IB-MECA|CF-102|CF102|C-Ibza-MU|(2S,3S,4R,5R)-5-(2-Chloro-6-((3-iodobenzyl)amino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrofuran-2-carboxamide|CI-IB-MECA|Namodenoson [USAN]|2Cl-IB-MECA|2-Chloro-N

规格或纯度：≥98%(HPLC)

英文名称：2-Cl-IB-MECA

生化机理：高亲和力和高度选择性的A3腺苷受体激动剂（Ki = 0.33 nM）。分别显示相对于A1和A2A受体的2500倍和1400倍的选择性。与不依赖Na +的腺苷转运蛋白相比具有高选择性。

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：Namodenoson (CF-102) 是一个选择性的 A3 腺苷受体 (A3AR) 激动剂 (Ki=0.33 nM)，选择性分别是 A1，A2 的 2500 和 1400 倍。An adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.A highly selective agonist of adenosine A3 receptor (Ki = 330 pM)

ALogP：1.9

IUPAC Name：(2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide

INCHI：InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1

InChi Key：IPSYPUKKXMNCNQ-PFHKOEEOSA-N

Canonical SMILES：CNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)Cl)NCC4=CC(=CC=C4)I)O)O

Isomeric SMILES：CNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=C(N=C32)Cl)NCC4=CC(=CC=C4)I)O)O

WGK Germany：3

PubChem CID：3035850

ChEMBL Ligand：CHEMBL431733

BindingDB Ligand：21221

CAS Registry No.：163042-96-4

GPCRdb Ligand：Cl-IB-MECA

溶解性：溶于DMSO, 最高浓度 (mg/mL) None, 最高浓度(mM) 100

敏感性：对光线 热敏感

熔点：207.0 to 211.0 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装