产品名称

英文名称：danirixin

同义词

Danirixin、954126-98-8、GSK1325756、GSK-1325756B、Danirixin (GSK1325756)、GSK1325756B、R318PGH5VP、(S)-1-(4-chloro-2-hydroxy-3-(piperidin-3-ylsulfonyl)phenyl)-3-(3-fluoro-2-methylphenyl)urea、1-(4-Chloro-2-hydroxy-3-(((3S)-piperidine-3-sulfonyl)phenyl)-3-(3-fluor

产品性质

CAS编号：954126-98-8

分子式：C19H22Cl2FN3O4S

分子量：441.90

PubChem编号：24780598

英文别名：Danirixin|954126-98-8|GSK1325756|GSK-1325756B|Danirixin (GSK1325756)|GSK1325756B|R318PGH5VP|(S)-1-(4-chloro-2-hydroxy-3-(piperidin-3-ylsulfonyl)phenyl)-3-(3-fluoro-2-methylphenyl)urea|1-(4-Chloro-2-hydroxy-3-(((3S)-piperidine-3-sulfonyl)phenyl)-3-(3-fluor

规格或纯度：97%

英文名称：danirixin

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Danirixin (GSK1325756)是高亲和力的选择性CXCR2拮抗剂，抑制CXCL8 (IL-8)结合的IC50值为12.5 nM。Product descriptionDanirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.

ALogP：3.1

IUPAC Name：1-[4-chloro-2-hydroxy-3-[(3S)-piperidin-3-yl]sulfonylphenyl]-3-(3-fluoro-2-methylphenyl)urea

INCHI：InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1

InChi Key：NGYNBSHYFOFVLS-LBPRGKRZSA-N

Canonical SMILES：CC1=C(C=CC=C1F)NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)C3CCCNC3)O

Isomeric SMILES：CC1=C(C=CC=C1F)NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)[C@H]3CCCNC3)O

PubChem CID：24780598

CAS Registry No.：954126-98-8

ChEMBL Ligand：CHEMBL3039531

Antibiotic DB：1194

GPCRdb Ligand：danirixin

溶解性：DMSO88mg/mL (199.14mM）；EthanolInsoluble；H2OInsoluble

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P260,P203,P318,P319

产品包装