产品名称

英文名称：SB415286

同义词

264218-23-7、SB 415286、SB-415286、SB415286、3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione、3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione、CHEMBL322970、1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amin、3-[(3-氯-4-羟基苯基)氨基]-4-(2-硝基苯基)-1H-吡咯-2,5-二酮

产品性质

CAS编号：264218-23-7

分子式：C16H10ClN3O5

分子量：359.72

MDL号：MFCD04039789

PubChem编号：4210951

别名：3-[(3-氯-4-羟基苯基)氨基]-4-(2-硝基苯基)-1H-吡咯-2,5-二酮

英文别名：264218-23-7|SB 415286|SB-415286|SB415286|3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione|3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione|CHEMBL322970|1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amin

规格或纯度：98%

英文名称：SB415286

生化机理：SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. 1 As a result of GSK3 inhibition, SB 415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 ?M. SB 415286 also protects primary neurons from death induced by the PI3-kinase pathway.Potent, selective GSK3 inhibitor (K i = 31 nM for GSK-3α); competes with ATP. Neuroprotective and antioxidant properties. Also able to stimulate glycogen synthesis and gene transcription. Cell-permeable.

法律信息：Sold for only research purposes

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：1mg卖完停产，不再备货。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍SB 415286 is apotent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and aKi of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β.产品用途SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.Product IntroductionSB 415286 is apotent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and aKi of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β.Product UsageSB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.

IUPAC Name：3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)pyrrole-2,5-dione

INCHI：InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

InChi Key：PQCXVIPXISBFPN-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

Isomeric SMILES：C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

WGK Germany：3

PubChem CID：4210951

CAS Registry No.：264218-23-7

ChEMBL Ligand：CHEMBL322970

Reactome Reaction：R-HSA-9687724

Reactome Drug：R-ALL-9687689

溶解性：DMSO 72 mg/mL Water <1 mg/mL Ethanol 72 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装