产品名称

英文名称：(±)-Evodiamine

同义词

XE178590、AS-15078、HY-N0114A、NCGC00163553-02、SureCN682158、FT-0651829、Evodiamine, Evodia rutaecarpa、NSC258314、NSC-258314、Evodiamine;、NCGC00163553-03、Q5418554、PubChem18244、(1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.0^{2,10.0^{4,9.0^{15,20]henicosa-2(10),、吴茱萸胺

产品性质

CAS编号：518-18-3

分子式：C19H17N3O

分子量：303.37

PubChem编号：151289

别名：吴茱萸胺

英文别名：XE178590|AS-15078|HY-N0114A|NCGC00163553-02|SureCN682158|FT-0651829|Evodiamine, Evodia rutaecarpa|NSC258314|NSC-258314|Evodiamine;|NCGC00163553-03|Q5418554|PubChem18244|(1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.0^{2,10.0^{4,9.0^{15,20]henicosa-2(10),

规格或纯度：98%

英文名称：(±)-Evodiamine

生化机理：The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis throμgh inhibition of vascular endothelial growth factor gene expression and inhibition of the ERK 1 (p44)/ERK 2 (p42) mitogen-activated protein kinase that correlated to endothelial cell angiogenesis. Promotion of apoptosis in human leukemic U937 cells is described with Evodiamine.

应用：An antiangiogenic and antiinflammatory agonist of TRPV1.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects.An antiangiogenic and antiinflammatory agonist of TRPV1.Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects.An antiangiogenic and antiinflammatory agonist of TRPV1.

IUPAC Name：21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one

INCHI：InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3

InChi Key：TXDUTHBFYKGSAH-UHFFFAOYSA-N

Canonical SMILES：CN1C2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3

Isomeric SMILES：CN1C2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3

PubChem CID：151289

Reaxy-Rn：94484

溶解性：Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25 °C, and ethanol (<1 mg/mL) at 25 °C

密度：1.39

敏感性：对光敏感

熔点：272°C(lit.)

产品包装