产品名称

英文名称：Corticosterone

同义词

(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one、A、HMS3713G06、(11.beta.)-11,21-Dihydroxypregn-4-ene-3,20-dione、Corticosterone, 1mg/ml in Methanol、NCGC0026090、皮质酮

产品性质

CAS编号：50-22-6

分子式：C21H30O4

分子量：346.46

Beilstein号：2339601

EC号：200-019-6

MDL号：MFCD00037715

PubChem编号：5753

别名：皮质酮

英文别名：(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one|A|HMS3713G06|(11.beta.)-11,21-Dihydroxypregn-4-ene-3,20-dione|Corticosterone, 1mg/ml in Methanol|NCGC0026090

规格或纯度：分析标准品

英文名称：Corticosterone

生化机理：Corticosterone is a hormone synthesized in response to stress. It binds and activates MCRs(mineralocorticoid receptors) and GRs (glucocorticoid receptors), which results in altered expression. This eventually affects ionic conductances throμgh the membrane. Corticosterone induces apoptosis in murine bone marrow.Potent endogenous glucocorticoid and mineralocorticoid receptor agonist (EC 50 = 20 nM, GR). Induces apoptosis. Modulates carbohydrate, potassium, and sodium metabolism in vivo . Blood-brain barrier permeable.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Corticosteroid is an activator of MCR.Corticosteroid is an activator of MCR.

IUPAC Name：(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

INCHI：InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChi Key：OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Canonical SMILES：CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O

Isomeric SMILES：C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O

WGK Germany：3

RTECS：GM7650000

PubChem CID：5753

溶解性：Soluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble in water.

密度：1.21

比旋光度：+221 to +226 deg(C=1, EtOH)

熔点：180-183°C

象形图：

信号词：Warning

危险声明：H317 May cause an allergic skin reaction

预防措施声明：P261,P280,P302+P352,P321,P501,P272,P333+P313,P362+P364

Merck Index：2538

个人防护装备：dust mask type N95 (US),Eyeshields,Faceshields,Gloves

产品包装