产品名称

英文名称：CD437

同义词

125316-60-1、CD437、AHPN、Cd 437、O-Desmethyl Adapalene、CD-437、6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid、Apoptosis Activator VI、6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid、6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-napht、CD 437、6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸

产品性质

CAS编号：125316-60-1

分子式：C27H26O3

分子量：398.49

MDL号：MFCD03106506

PubChem编号：135411

别名：CD 437|6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸

英文别名：125316-60-1|CD437|AHPN|Cd 437|O-Desmethyl Adapalene|CD-437|6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid|Apoptosis Activator VI|6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid|6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-napht

规格或纯度：≥98% (HPLC)

英文名称：CD437

生化机理：CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.Potent, cell-permeable RARγ-selective agonist (EC 50 values are 140, 28 and 7 nM for RAR-α, β and γ respectively). Shows RARγ-dependent and -independent effects on differentiation and apoptosis. Shows antitumor effects in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：CD 437 is a synthetic, cell-permeable, retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer. CD 437 is an activator of RAR γ.A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducerCD 437 is a synthetic, cell-permeable, retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer. CD 437 is an activator of RAR γ.A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer

IUPAC Name：6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid

INCHI：InChI=1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)

InChi Key：LDGIHZJOIQSHPB-UHFFFAOYSA-N

Canonical SMILES：C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O

Isomeric SMILES：C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O

WGK Germany：3

RTECS：QJ1975900

PubChem CID：135411

CAS Registry No.：125316-60-1

ChEMBL Ligand：CHEMBL1180

Antibiotic DB：1687

象形图：

信号词：Warning

危险声明：H361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P203,P318

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装