产品名称

英文名称：Laquinimod

同义词

908SY76S4G、HY-13010、5-CHLORO-N-ETHYL-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE、FMOC-CL ChloroforMic acid 9-fluorenylMethyl ester、MFCD08689859、5-Chloro-N-Et-4-hydroxy-1-methyl-2-oxo-N-Ph-1,2-dihydroquinoline-3-carboxamide、AKOS005、拉喹莫德

产品性质

CAS编号：248281-84-7

分子式：C19H17ClN2O3

分子量：356.8

PubChem编号：54677946

别名：拉喹莫德

英文别名：908SY76S4G|HY-13010|5-CHLORO-N-ETHYL-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE|FMOC-CL ChloroforMic acid 9-fluorenylMethyl ester|MFCD08689859|5-Chloro-N-Et-4-hydroxy-1-methyl-2-oxo-N-Ph-1,2-dihydroquinoline-3-carboxamide|AKOS005

规格或纯度：≥98%

英文名称：Laquinimod

生化机理：Laquinimod (ABR-215062) is a potent immunomodulator. Laquinimod is a novel oral drμg that is currently being evaluated for the treatment of relapsing-remitting (RR) multiple sclerosis (MS). Laquinimod has demonstrated significant activity in suppressing experimental autoimmune encephalomyelitis, an animal model of RRMS. In phase I and II clinical trials, the drμg was well tolerated, with some hints of efficacy in small numbers of patients with RRMS. While the mechanism of action of the drμg is unknown, it likely involves Th1 to Th2/Th3 immune deviation, promotion of the synthesis and release of neurotrophic factors, and other possible neuroprotective effects. A Phase II study of Laquinimod in active lupus arthritis patients is currently ongoing, if successful, will lead to the approval of the first oral immunomodulatory drμg for suppressing multiple sclerosis disease activity.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：250mg卖完停产，不再备货

产品介绍：Laquinimod是有效的免疫调节剂。Phase 3。产品介绍Laquinimod是一种有效的免疫调节剂，可预防中枢神经系统的神经变性和炎症。Laquinimod is a potent immunomodulator. Phase 3.

IUPAC Name：5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide

INCHI：InChI=1S/C19H17ClN2O3/c1-3-22(12-8-5-4-6-9-12)19(25)16-17(23)15-13(20)10-7-11-14(15)21(2)18(16)24/h4-11,23H,3H2,1-2H3

InChi Key：GKWPCEFFIHSJOE-UHFFFAOYSA-N

Canonical SMILES：CCN(C1=CC=CC=C1)C(=O)C2=C(C3=C(C=CC=C3Cl)N(C2=O)C)O

Isomeric SMILES：CCN(C1=CC=CC=C1)C(=O)C2=C(C3=C(C=CC=C3Cl)N(C2=O)C)O

PubChem CID：54677946

CAS Registry No.：248281-84-7

ChEMBL Ligand：CHEMBL66092

Wikipedia：Laquinimod

DrugCentral Ligand：4825

溶解性：DMSO 61 mg/mL (170.96 mM);Water <1 mg/mL (<1 mM);Ethanol 1 mg/mL (2.8 mM)

象形图：

信号词：Danger

危险声明：H341 Suspected of causing genetic defectsH302 Harmful if swallowedH332 Harmful if inhaledH360 May damage fertility or the unborn childH302+H332 Harmful if swallowed or if inhaledH362 May cause harm to breast-fed children

预防措施声明：P261,P280,P405,P501,P264,P260,P281,P271,P270,P304+P340,P330,P263,P203,P301+P317,P318,P317

产品包装